ID A0A1C4VUY4_MICVI Unreviewed; 485 AA.
AC A0A1C4VUY4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=argininosuccinate lyase {ECO:0000256|ARBA:ARBA00012338};
DE EC=4.3.2.1 {ECO:0000256|ARBA:ARBA00012338};
GN ORFNames=GA0074695_1804 {ECO:0000313|EMBL:SCE87635.1};
OS Micromonospora viridifaciens.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1881 {ECO:0000313|EMBL:SCE87635.1, ECO:0000313|Proteomes:UP000198242};
RN [1] {ECO:0000313|EMBL:SCE87635.1, ECO:0000313|Proteomes:UP000198242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43909 {ECO:0000313|EMBL:SCE87635.1,
RC ECO:0000313|Proteomes:UP000198242};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000985};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3.
CC {ECO:0000256|ARBA:ARBA00004941}.
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DR EMBL; LT607411; SCE87635.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4VUY4; -.
DR OrthoDB; 4899737at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000198242; Chromosome i.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW Lyase {ECO:0000313|EMBL:SCE87635.1}.
FT DOMAIN 43..291
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 360..389
FT /note="Argininosuccinate lyase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14698"
SQ SEQUENCE 485 AA; 51209 MW; 5194824CB9357867 CRC64;
MSTPALTTYQ RHHLAPTYDH HVGHLYPAMV RASQAHVVML TEQGLIPAER GARLLRGLAE
LRADTGPAPA YDGSFEDTYY LMEKRLAEAC GIPTSELDVQ LARSRNDLDA GVFRMLLRDQ
LLGVLDRVLA TGRTALDRAD RYADVVITGY THRRPAQPTT IGHALAGYAE ALAGEAAAYA
DLIDQLNISP LGSCAFAGTD LDIAPARVAE LLGFAGLVTN SYEAVAGADH LVRVGTLNAQ
ALATGARLAR TLMDWLSWNW VTTPADFTQG SSIMPQKRNP VVLEHLVSYA GAAAADAASV
LNNVGAAWWE DSNNATTDVQ VRLWESNDRA ERFFALVGGF LAELAPLSPP SREEIVASGA
TTTAAADALT RHGVPFRAAH SVVGRLVRAG APDTWTAEGV RAAAEGLTGP LDDAAVADLI
AAAVRPDLVL NRAQVDGPGA AAVRAQVGTL RVAFDGVADR LAAVRDRLGR ADAALDAVAA
ELVAR
//
