ID A0A1C4W4R6_9ACTN Unreviewed; 1212 AA.
AC A0A1C4W4R6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GA0070612_2121 {ECO:0000313|EMBL:SCE91202.1};
OS Micromonospora chokoriensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=356851 {ECO:0000313|EMBL:SCE91202.1, ECO:0000313|Proteomes:UP000198224};
RN [1] {ECO:0000313|EMBL:SCE91202.1, ECO:0000313|Proteomes:UP000198224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45160 {ECO:0000313|EMBL:SCE91202.1,
RC ECO:0000313|Proteomes:UP000198224};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; LT607409; SCE91202.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4W4R6; -.
DR Proteomes; UP000198224; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 59..371
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 376..686
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..810
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 80..87
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1212 AA; 127144 MW; 8075024ABF09143A CRC64;
MQAYRLVRRS GGPAREGDGG PGGSTVAAGG TVLPDHDTPV AGGSGLSDRP GEPVAAPGRR
VDPVQAEVVG HTDGPMLVLG GPGTGKTSTL VEAVAARVAD GVDPERILVL TFGRRGATAL
RQRIEARIAQ DGHRVLREPL VRTFPAYAFG LLRRAAAERG EPSPRLLTGP EQDLIIRELL
DVVGEEPEDD PVGWPSDLRP ALRTRAFAGQ LRDLLMRAAE RGVGPVDLAR LGEKLGRDDW
PAAARFLREY VSVLALRDVS NRGSIAYDPA ELVRAATGLL RDDEELLAAE RRRLAHVYLD
ELADTDPAQL ELLSVIAGGG TSLVAFADPD SSTYAFRGAD PTGVATFPHR FRTASGAPAA
QVLLTTSYRA GPDLLAAVAR LGRRLRGPAA HRRLHPLPDA PPGTVEVHTF RSATSEAAWL
AHSLRSAHLL DGVPWSRMAV LVRSTALQLP TLRRALHAAG VPTVVHGEDL PLHLQPAVAP
LLLLLRCALE PDRLDEEAAV ALLHSPLGGA DPLAERRLRQ GLRALALAGG DRRPSGELIV
EALRDPAELA DIDRHWAEPA QAVAGLLACA RDAAARPGST AEDVLWAVWH ASNLAERWAG
AIIQGRPAAG EGDLARRRRA EAADRDLDAV LVLFDAAARF TDRLPGARTE VFLDHVLAQD
LPADTIAPTA DRGAAVRLLT AHAAKGLEWD LVAVAGVQEG IWPDLRLRGS LLGSERLVDV
LAGRSVDGAT AANVVGQTSA LLDEERRLFH VAISRARHRL LVSAVASAAV GGDDHEEQPS
RFLHELVPHT PPRPPDGTGP ADPTAPPGPR NGPQRGGATG GVPGGTSSAA GTHADGGRTD
GRTDDGTPSA DGGTGVGAGG DVNDGDGEAD RPGALPVTRP PRALTLPALV AELRTAITDP
AAPAGRRRAA AAELARLAVA GVPGAHPDDW WGLRALSDDR PLVDEGEPVR VTPSAMESAL
RCSLRWLLER HGGSGPTSTA QGVGNLVHAA AMLAEDASAD RGALLDYVAA RFDAIELAAR
WMAGPERERA EAMVDKLLRW LATNPRRLLA IEHEFAVRLD DPNRPVDLAG RVDRLEIDEA
GRLVVIDLKT GKSTAVTGAE LAEHPQLGAY QAAVEAGAFA EFGDESGGAA LVQLGTSAKD
AREQNQPAAG EGPAAGWATA LVRRTADTMA AATFAAVANS KCRVCPVRTS CPVSGQGRQV
VEPPTARPSD NP
//
