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Database: UniProt
Entry: A0A1C4W5Y3_9ACTN
LinkDB: A0A1C4W5Y3_9ACTN
Original site: A0A1C4W5Y3_9ACTN 
ID   A0A1C4W5Y3_9ACTN        Unreviewed;       580 AA.
AC   A0A1C4W5Y3;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   05-JUN-2019, entry version 15.
DE   SubName: Full=HAMP domain-containing protein {ECO:0000313|EMBL:SCE91594.1};
GN   ORFNames=GA0070607_3173 {ECO:0000313|EMBL:SCE91594.1};
OS   Micromonospora coriariae.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Micromonospora.
OX   NCBI_TaxID=285665 {ECO:0000313|EMBL:SCE91594.1, ECO:0000313|Proteomes:UP000198243};
RN   [1] {ECO:0000313|EMBL:SCE91594.1, ECO:0000313|Proteomes:UP000198243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44875 {ECO:0000313|EMBL:SCE91594.1,
RC   ECO:0000313|Proteomes:UP000198243};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; LT607412; SCE91594.1; -; Genomic_DNA.
DR   Proteomes; UP000198243; Chromosome i.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198243};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37    580       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008706565.
FT   TRANSMEM    187    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      212    264       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      300    514       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   REGION      520    580       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1C4W5Y3}.
FT   COILED      149    176       {ECO:0000256|SAM:Coils}.
FT   COILED      252    297       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    552    580       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A1C4W5Y3}.
SQ   SEQUENCE   580 AA;  62926 MW;  AE43BBC11763735C CRC64;
     MTPVFGGWSL RRRVITLLTI VGVLLIGLAG AEAAMAARNR TQIDAILNET GPLRVQAQEL
     LNAVLDQETA VRGYAVSGDQ NDLGPYQAGL DQEKKVVAAM QALLDNYPQI GQELRTVEER
     AEQWRQSVAV PVISTTEQSG TSAGQALVTE QARQQFDEVR AAIDDLQQEI LAAREQSAAD
     VRNSSNLLVA LLIIAALVVV VAGAVLLVSL DRMVVRPLIG LADQVREVAK GDYQHGIATT
     GPPEFVQLGA DVDAMRQKIA SDLAEVREAR ERIEWVNSQL QKQAEELTRS NRDLEQFAYV
     ASHDLQEPLR KVASFCQLLQ RRYAGQLDER ADQYIAFAVD GAQRMQRLIN DLLAFSRIGR
     LTSGFVEVDL NKVMGDVAGQ TEAARQYADA ELTWTELPVI RGEEPLLTNL LANLVSNSIK
     FRRPDAPPKV HISARLVGAE WEISCQDNGI GIEPEFADKI FVIFQRLHSK DAYPGTGIGL
     AIVKKIVEYH GGRVWVDTDV PEGTAIRFTL PALPEDVEAA AAAAGTPEPP QAAADATGDA
     VPSNETPATP AERSDGADRP DRADGSPESG RTGDMRETVG
//
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