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Database: UniProt
Entry: A0A1C4WCZ1_9ACTN
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ID   A0A1C4WCZ1_9ACTN        Unreviewed;       361 AA.
AC   A0A1C4WCZ1;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=GA0074696_1784 {ECO:0000313|EMBL:SCE94117.1};
OS   Micromonospora purpureochromogenes.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Micromonospora.
OX   NCBI_TaxID=47872 {ECO:0000313|EMBL:SCE94117.1, ECO:0000313|Proteomes:UP000198228};
RN   [1] {ECO:0000313|EMBL:SCE94117.1, ECO:0000313|Proteomes:UP000198228}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43821 {ECO:0000313|EMBL:SCE94117.1,
RC   ECO:0000313|Proteomes:UP000198228};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; LT607410; SCE94117.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000198228; Chromosome i.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198228};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       53    342       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   361 AA;  38085 MW;  84A9479460E3043E CRC64;
     MTTPETDAVI DQRIDRVVPL TTPALLLHDL PLRAPLASAV LAGRRAVGRV LDRADDRLLV
     VVGPCSVHDP AAALEYAHLL CEAADRHADD LLVVMRVYFE KPRSTVGWKG LINDPALDGS
     GDVNLGLRTA RALLLDVLRL GLPVGCEFLD PITPQYIADT VAWGAIGART VESQVHRQLA
     SGLSMPIGMK NRPDGSIGTA VDAIRAAGVP HVFPGIDVSG TPAIMHTRGN ADGHLVLRGG
     GGRPNYDAES VAGALDLLRA AGLPERLVVD ASHANSGKDH RNQPKVAADV AAQLAAGQRG
     IVGIMLESFL LEGRQDLDPT RELTYGRSVT DACIGWDTTA EVLDHLAAAV RGRRAALPTP
     A
//
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