ID   A0A1C4WHJ9_9ACTN        Unreviewed;       596 AA.
AC   A0A1C4WHJ9;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:SCE95650.1};
GN   ORFNames=GA0070607_3651 {ECO:0000313|EMBL:SCE95650.1};
OS   Micromonospora coriariae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=285665 {ECO:0000313|EMBL:SCE95650.1, ECO:0000313|Proteomes:UP000198243};
RN   [1] {ECO:0000313|EMBL:SCE95650.1, ECO:0000313|Proteomes:UP000198243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44875 {ECO:0000313|EMBL:SCE95650.1,
RC   ECO:0000313|Proteomes:UP000198243};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; LT607412; SCE95650.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4WHJ9; -.
DR   OrthoDB; 3216872at2; -.
DR   Proteomes; UP000198243; Chromosome i.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 2.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   4: Predicted;
FT   DOMAIN          7..185
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          188..285
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          316..494
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          497..592
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   596 AA;  63488 MW;  E8395AFADEF12574 CRC64;
     MAREFSTVGV VGLGTMGAGI VEVFARNGID VVAVEISEPA VERGRVTLTG STDRAVAKGK
     LAPEDRDALL GRVHFAVGLD ALHSVDLVIE AVPEHLDLKQ RIFAELDRVC KPEAILATNT
     SSLSVTEISV ATHRPNQVIG IHFFNPAPVM KLVEVVRTVV TSAEVVADVE ALCARLGKVD
     VTINDRAGFI ANALLFGYLN HAVGMFESHY ATREDIDAAM KLGCGLPMGP LALMDLIGLD
     TAYEILDTMY RRGGRDRRHA PVPLLKQMVT AGLLGRKSGR GFYTYERPGS PVVVPDEATP
     LATEAALADG ARAIAKVGVV GSGTMATGII EVFAKAGYEV ISVTRGAEKS AKVCEAVKTS
     LNKGVVRGKL AEADRDAALG RISWSATLDH LADVDLVVEA VVEELSVKKA LFASLDEICK
     PGVVLATTTS SLPVIDVAMA TQRPADVVGL HFFNPAPVMP LVEVVRTIRT SPETTATARA
     VCAALGKTGV VCGDRSGFIV NALLFPYLND AVKMLEASYS TADDIDYAMK LGCGYPMGPF
     ELLDVVGLDV SLAIQRELYL ELREPGFAPA PLLEHLVTAG YLGRKTRRGF RDHSHR
//