ID A0A1C4XKT9_9ACTN Unreviewed; 429 AA.
AC A0A1C4XKT9;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=GA0070607_5419 {ECO:0000313|EMBL:SCF09053.1};
OS Micromonospora coriariae.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=285665 {ECO:0000313|EMBL:SCF09053.1, ECO:0000313|Proteomes:UP000198243};
RN [1] {ECO:0000313|EMBL:SCF09053.1, ECO:0000313|Proteomes:UP000198243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44875 {ECO:0000313|EMBL:SCF09053.1,
RC ECO:0000313|Proteomes:UP000198243};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; LT607412; SCF09053.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4XKT9; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000198243; Chromosome i.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
SQ SEQUENCE 429 AA; 48467 MW; 1D38886E614404C4 CRC64;
MSTHDFIAIG LGPYNLGLAC LTAPIEELDG VFLEARPSLA WHPGMLLESA RLQTPFIADL
VSLADPTSAY SFLNYLKEIG RLYPFYIRES FYPLRSEYDA YCRWAAAKLP NLRFGQAVTT
VEYDPADERY VVRADTGAGE SVEYRARHLV LGTGTPPHLP PAVAGLPRDA VHNSRYLEHR
DALRTKRSIT VVGSGQSAAE IYHDLLGDLG RYGYQLNWVT RSPRFFPLEY TRLTLEMTSP
DYVDYFHVLP EATRYRLESE QKGLFKGINA DLINDIFDLL YAHSVDGPVN TRLLTNTELT
SADHHDGAYT LGLRQVEQER DFTLRTEGLV LATGYRYRVP EFLTPVRDRI RWDAHGRFDV
ARNYSIDHTG RGIFLQNAGT HTHSITSPDL GMGAYRNSWI IRELLGREHY PIEKSITFQE
FGAPAGVAS
//
