ID   A0A1C4YET2_MICEC        Unreviewed;       500 AA.
AC   A0A1C4YET2;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Potassium/proton antiporter, CPA1 family {ECO:0000313|EMBL:SCF19235.1};
GN   ORFNames=GA0070618_3912 {ECO:0000313|EMBL:SCF19235.1};
OS   Micromonospora echinospora (Micromonospora purpurea).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1877 {ECO:0000313|EMBL:SCF19235.1, ECO:0000313|Proteomes:UP000198253};
RN   [1] {ECO:0000313|EMBL:SCF19235.1, ECO:0000313|Proteomes:UP000198253}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43816 {ECO:0000313|EMBL:SCF19235.1,
RC   ECO:0000313|Proteomes:UP000198253};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; LT607413; SCF19235.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4YET2; -.
DR   InParanoid; A0A1C4YET2; -.
DR   OrthoDB; 9810759at2; -.
DR   Proteomes; UP000198253; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR   PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR   PROSITE; PS51202; RCK_C; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        61..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        86..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        120..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        240..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          399..480
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
SQ   SEQUENCE   500 AA;  52467 MW;  183C25D0C23AA24A CRC64;
     MTHDLDVALL LGAAVLLVAI GAVRFSTRLG VPSLLVYLAL GVLIGRSGLG IRFDDAELTR
     MLGFCALIVI IAEGGLTARW STLRPVLGLA TALSTVGVLV SILVVGIALH LLLDLDWRLA
     LLYGAVLSST DAAAVFATLR RLRLPPRLVA TLEAESGMND APVVLLVVLL SRGFPLAHPW
     WYEVLLVGYE LAAGAAVGFA AGHLGRLALR RAALPSAGLY PIAVVGFTVL AYAVGASVHA
     SGFLAVYVAG VLLGNARLPH RQAILGFADG LAWLAQIGLF VLLGLLVTPA RLDEAILPAM
     VAGLALLFLA RPLSVAAAAA PFRFGIREQA FLSWAGLRGA VPIVLATIPL SAGVPGADRL
     FDSVFVLVVI FTLVQAGTLA PVARRLRVTA PAEPAEIRVE TAPLERMRAD LLQLEVPAGS
     RLAGVHVDEL RLPLGASVTL VLRDGTGFVP GPDTRLKVGD SLLIVATDGV RDEAERRLRA
     VSRRGRLARW FGETGTDSGD
//