UniProt: A0A1C4YME5

Database: UniProt
Entry: A0A1C4YME5_9ACTN

LinkDB:  A0A1C4YME5_9ACTN 
Original site:  A0A1C4YME5_9ACTN

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Ontology (4)   
   GO (4)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (41)   
   InterPro (22)   
   Pfam (9)   
   PROSITE (4)   
   SMART (6)   
All databases (46)   

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ID   A0A1C4YME5_9ACTN        Unreviewed;      3553 AA.
AC   A0A1C4YME5;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:SCF21925.1};
GN   ORFNames=GA0070612_4982 {ECO:0000313|EMBL:SCF21925.1};
OS   Micromonospora chokoriensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=356851 {ECO:0000313|EMBL:SCF21925.1, ECO:0000313|Proteomes:UP000198224};
RN   [1] {ECO:0000313|EMBL:SCF21925.1, ECO:0000313|Proteomes:UP000198224}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45160 {ECO:0000313|EMBL:SCF21925.1,
RC   ECO:0000313|Proteomes:UP000198224};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; LT607409; SCF21925.1; -; Genomic_DNA.
DR   Proteomes; UP000198224; Chromosome i.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF21089; PKS_DH_N; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 2.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 2.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SCF21925.1}.
FT   DOMAIN          33..459
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1670..1745
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1764..2190
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3401..3476
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3553 AA;  369531 MW;  120984C98997B519 CRC64;
     MLTEDKLLDY LKRVTADLHQ TRQRLREVEA GEQEPIAIIG MGCRFPGDVR TPEDLWQLLL
     DGRDAMAEFP DDRGWDLDAL FGDGTGAAGT SDARQAGFVY DAADFDAAFF GISPREATAM
     DPQQRMLLEV TWEALEQAGI DPVTLKGSQT GVFAGTAGQD YGTLLLGASV GLEGHLLTGN
     AAAVVSGRIS YCLGLEGPAV TVDTACSSSL VALHLAAQAL RQQECGLALA GGATVMATPG
     AFLEFSRQGG LSGDGRCKAF AAAADGTGWA EGAGVLVLER LSDAQRNGHQ VLAVIRGSAV
     NQDGASNGLS APNGPAQQRV IQRALANAGL TPNQIDTVEA HGTGTSLGDP IEAQALIATY
     GQDRDPQRPL WLGSIKSNLG HTQAAAGVAG IIKMVLAMRA GVLPQTLHVD EPTPQVDWSE
     GAVELLTSRQ PWPRTDAPRR SAVSSFGVSG TNVHVVLEQA PVLADDTAPE ATAAPDGPWL
     LSGRTERALR AQAAKLLARV AGDDRVDLRD VAYALTADRS TFDHRAVILP GDRADLVHRL
     AALAEGRLDT GVLTGQRQPA RTAFLFSGQG SQRAGMGSDL AATYPVFAAA FDEVCDALQP
     HLEQPLRQVI AENPDGLLDQ TAYTQAGLFA VEVALYRLVE SWGIVPDHLI GHSIGELAAA
     HVAGVLSLAD AATLVAARGT LMQALPAGGV MVAVRATEAE VLPLLTDGVS IAAVNGPRSV
     VLSGEQQAVE AVAATFGRAK RLTVSHAFHS ALMEPMLDDF RRVAESVTYH EPQIPIVSNV
     TGRLDERLDA AYWVRHVRDA VRFADGIAAL VDAGVTTLVE IGPGGVLTAL ADECLTGDQV
     AVPTLRKDRP EPEALLAALG RLHVDGVSPD WRAVLPAGRP VHLPTYAFQH ERYWPDTSRR
     WTGDLTNVGV RPAGHPLLGA AVALADGGGF LYTGRLSLER HSWLADHAVQ GTVLVPGTGF
     VELALRAGEQ VGTGHLRELT LQAPLVLPER GDTELQVSVG PAEDDGSRAV TIHSRAVDST
     DPDTPWTCHA VGVVQTVEAS TTDWRDFTTW PPADARPADL TGFYDRLAAQ GFTYGPAFQA
     LQRAWVAGEY AYAEVRIPDG SGTDAADFGL HPALLDAAMH ATGLLPARTT EQGNRLPFAW
     NDVALHAAGA TDLRVRVRIA ENADVSVAVA DATGAPVAEV RMLTLRPISA DQLATPDDTL
     FHVDWPTVTT TGVDTGRIAI LGDDLPELAD LDADRYPDLA ALGVALAGGA DRPDLVLAGC
     SAADSDPEST HATTVAALVT AQHWLDDPAF DGARLVVVTR QAIATGPDED VTDLSAAPVW
     GLLRSAQSEN PDRFVLADLD GHPASAGRLI EAVTSGEPQV AVRRGTVRVP RLARLAPPRE
     PNPPLDPDGT VLITGATGTL GGLLARHLVT RHGVRHLLLT SRRGSAAEGS AELCAELTTL
     GAAVTLAACD TADRAAVAAL LASVPAEHPL TAVVHAAGVS DDGVVSALTP GRVGAVLRPK
     VDAAHHLHDL TRDADLSAFV LFSSLAATLG GGGQGNYAAA NAYLDALAQH RRASGLPGVS
     LVWGLWDARS GMSEHLDDTH FSRIARGGII SMPSADALAL FDRAIAAPVP VVAPARLDFA
     TLRAQGAQGG VPALLRGLVR VPGGKPGART RAGNAFLTHL AALAEADRER ALLDLVRGQA
     AAVLGHSGPA AVPPQQPLSE LGVDSLTAVE IRNQLGGATG LRLPATLIFD YPTPQALAGY
     LHEQLGGIEA PTAASTEAAP VAADEPIAIV GMACRYPGGV RTPEDLWQLV DLGTDGITGV
     PEDRGWDIAG LYDPEADRPG GFYVREGGFL DDATDFDAAF FGISPREAVA MDPQQRVLLE
     VSWEAIERAG IDPVSLRGSR TGVFAGTSGQ DYGGVLGRDP SSVGGFGLTS TTASVISGRV
     SYALGLEGPS LSVDTACSSS LVALHLAAQA LRQGECSLAL VGGVMVMATP AAFVAFSQQR
     GLAPDGRCKS FAGSADGIGW AEGAGVLVVE RLSDARRNGH HVLAVVRGSA INQDGASNGL
     TAPNGPSQQR VIRAALANAG LSSADVDVVE AHGTGTVLGD PIEAQALLAT YGQGRPADRP
     LRLGSIKSNI GHAQAAAGVA GIIKMVAAIR NETMPRTLHV DEPTPEVDWS AGAVELLTDA
     RPWEAYGRPR RAGVSSFGVS GTNAHVIIEE APVAPADEPT VVSPDVPWVL SGRTATAVAD
     QARRLAAVES EPAEVAHSLL SRSEFVQRAV VLGPDHRPGL AALADGMPSS AVVSGVARSS
     GVVFVFPGQG SQWVGMAAEL LESEPVFAAR VAECAAALAP FVDWNLLDVL RSDDPLERVD
     VVQPVLWAVH VALAEVWKAK GVTPDAVIGH SQGEIAAACV AGVLSLSDAA KVVALRSKAL
     LALSGSGGMV SVSAGLDVVT PLLTEGVSVA VVNGPTSVVV AGADLDAFLA AAEVAGVRAR
     RVKVDYASHC ALVEPVEAEL ARLLDGVQPL PGAVPVFSTV EGGGVMDAAY WYRNLRQPVR
     LDLAVEAAHA AGHRIFVEVS AHPVLTGAIA DAVDVATVGT LRRGEGGTAQ IVRALAEAWV
     QGAPVDWTTV IPATRTVDLP TYPFQHQRFW VDEVNLPISA DIATAGLDAA SHPMLGAAIP
     LLDSDAVLFT GLLSVEAHPW LGEHKVMGAN VMPGTAFVEL ALHVAGQTGC RRLEELTLLT
     PLIVPERGAR QLQLWVGPPD GNGRRAINVR SRSDEGETGD PLDATGWIHH ATGAISTAAD
     PTGPADLTAW PPPGARPVDL SEFYEAVSRT AFDYGPMFQG LRAAWVTEDD VYAELSLPES
     GRAAAGAYGM HPALLDAGLQ AMSLNTFLTR MGDGEPAERS RLPFVWSGIS LHTTGSSSFR
     IRLKPAGAVG VSFTVADSTG APVAEIDSLI MRPVSADRLA SARGGDHESL YRLDWTPVLP
     GTAPATAVVG VDPYQLTRVA GTGYPDLAAL ADAPVVPDLV FVTLEADPQA AAEPGIGARR
     RTTIALDLVQ RWLAEPAFGA SRLVVVTRGA VAANTGDPAG DLAAAAAWGL IRTAQAENPD
     RFVLLDLDDD PTSLTVAVPA VASGEPQVVV RAGRPLAPRL APVPVAPEPR ADIAGGDPDG
     TVLITGGTGT LGGLLARHLV TEHGARRLVL TGRRGSAADG VDALVTDLTE LGAQVVVEAC
     DATDRDALAA VLDRIPADQP LTVVHAAGAL DDGVVTALTP DRIDAVLAPK TDAAWNLHLL
     TTDRKVARFV LFSSAAGVLG GAGQGNYAAA NAFLDELARH RRALGLPAES LAWGLWEQAS
     GMTGHLDGAD LRRVARGGVR RLPTARALAL FDTAGVLDEP LLVPADLDLA GLRHQPVETV
     PALLRGLVRG AARPVTEPAG GPSVVGLAQR LAGLADEDAD ALVLQVVRAN VAAVLGYPGP
     DDVDPTLPFK ELGFDSLTAV ELRNRLNVAT GLRLRATLVF DYPNAHSLAA YLRAQVVPDE
     AGAAEPLLAE LSRIEAAVAT LPGDGSVREQ VTSRLRDLLA GLEPTGAADV TQDLESATDD
     EMFEFITREF GVS
//

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