GenomeNet

Database: UniProt
Entry: A0A1C4YWS5_9ACTN
LinkDB: A0A1C4YWS5_9ACTN
Original site: A0A1C4YWS5_9ACTN 
ID   A0A1C4YWS5_9ACTN        Unreviewed;       466 AA.
AC   A0A1C4YWS5;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Signal transduction histidine-protein kinase/phosphatase MprB {ECO:0000256|ARBA:ARBA00040454};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE   AltName: Full=Mycobacterial persistence regulator B {ECO:0000256|ARBA:ARBA00041776};
GN   ORFNames=GA0070612_5375 {ECO:0000313|EMBL:SCF25086.1};
OS   Micromonospora chokoriensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=356851 {ECO:0000313|EMBL:SCF25086.1, ECO:0000313|Proteomes:UP000198224};
RN   [1] {ECO:0000313|EMBL:SCF25086.1, ECO:0000313|Proteomes:UP000198224}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45160 {ECO:0000313|EMBL:SCF25086.1,
RC   ECO:0000313|Proteomes:UP000198224};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LT607409; SCF25086.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4YWS5; -.
DR   eggNOG; COG0642; Bacteria.
DR   Proteomes; UP000198224; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR   PANTHER; PTHR44936:SF9; SENSOR PROTEIN RSTB; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SCF25086.1};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          155..207
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          215..429
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   REGION          446..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   466 AA;  49226 MW;  E2D352D4FB7FEA2E CRC64;
     MCSLVALAFL IPLGLSLREQ SRDEAIADAA RRSALVTGAL AVSTDPAVVE RAVVASAEGS
     DFPPVVHGLG LDESTGRAGG DDLDRARADK RSLVVDVDGG VVRLDPVVLG DRTAVVEVFL
     PDSSLGEGGG TWMLLFAVGA AMAGAAVLVV DRVAARAVDS TKGLVKAALS IGDGDLGVRV
     EPTGPRELAE AGYAFNRMAD RLDAARTDER ELVADLSHRL RTPLTVLRLD AEALESDDTS
     VGSFSPAELD RLRGIRRIRQ AIVTLEGEID VLIKTTRKAV AHEAGPAMCD VSEVVRDRMV
     FWAALAGDQN RPHRVNGAQL RIPAPVPRAE LAAALDAVIG NVFRYTPQGT AFEVAVSRRD
     GYVAIRVDDA GPGIANPDRA LRRGASDQGS TGLGLDIAKR VALQANGSVS IDRARLGGAS
     VVMLLADPEA TPRQVSRFGL VGRMARDARD TKATGRRWPR QRPTDE
//
DBGET integrated database retrieval system