ID A0A1C4Z9J8_MICVI Unreviewed; 500 AA.
AC A0A1C4Z9J8;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GA0074695_5273 {ECO:0000313|EMBL:SCF29606.1};
OS Micromonospora viridifaciens.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1881 {ECO:0000313|EMBL:SCF29606.1, ECO:0000313|Proteomes:UP000198242};
RN [1] {ECO:0000313|EMBL:SCF29606.1, ECO:0000313|Proteomes:UP000198242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43909 {ECO:0000313|EMBL:SCF29606.1,
RC ECO:0000313|Proteomes:UP000198242};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT607411; SCF29606.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4Z9J8; -.
DR Proteomes; UP000198242; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SCF29606.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 28..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..250
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 258..495
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 500 AA; 52865 MW; 0192469152630985 CRC64;
MRVKGRAPSY RLGYRKGPRL TLGLRGRLMV LGVLGLSVGF AFGGVLLLGA LGWTLQRTID
AEAFQTADAV AQLAAEDSLP DPLPVAGGQL RVQVVDAQGR IRAASIDADR LVPMLRPDQL
RAGQRQRLVV DGRRVGLAGP VRVVTVPAGN PGEPLTVLVA KSMADVQHSL RVVRILLLVG
FPLLVAGLAV VAWRVIGATL RPVEALRSGA AEITGRAGPG QLPVPAGRDE IHRLAVTLND
MLDRLETSRA RQRAFVADAA HELRSPLTNM RTELEVARRL GDATDWPAVA DNLLADTERL
GRLVDDLLLL ARLDEQAARP AAPSSRPVGP VELGELLRSV AGRYPSPPVR LAPPPGPLWT
EGDLGELRRV LANLVENALR HARGEVLLAV TGPHPDPPVP GQCGAAPAAG AYHLVTVTDD
GPGIPAADRE RVFARFTRLD DARARDDGGA GLGLAIVREL VRRAGGDVEL SDAAPREAAS
TGPGLRVTVR LPALDDPEAA
//
