ID   A0A1C4ZWJ7_MICEC        Unreviewed;       342 AA.
AC   A0A1C4ZWJ7;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=O-methyltransferase {ECO:0000313|EMBL:SCF37315.1};
GN   ORFNames=GA0070618_5892 {ECO:0000313|EMBL:SCF37315.1};
OS   Micromonospora echinospora (Micromonospora purpurea).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1877 {ECO:0000313|EMBL:SCF37315.1, ECO:0000313|Proteomes:UP000198253};
RN   [1] {ECO:0000313|EMBL:SCF37315.1, ECO:0000313|Proteomes:UP000198253}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43816 {ECO:0000313|EMBL:SCF37315.1,
RC   ECO:0000313|Proteomes:UP000198253};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; LT607413; SCF37315.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4ZWJ7; -.
DR   InParanoid; A0A1C4ZWJ7; -.
DR   OrthoDB; 582216at2; -.
DR   Proteomes; UP000198253; Chromosome i.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   PIRSF; PIRSF005739; O-mtase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:SCF37315.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:SCF37315.1}.
FT   DOMAIN          168..322
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
FT   ACT_SITE        251
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ   SEQUENCE   342 AA;  38013 MW;  BB56A52032D1EF0D CRC64;
     MSTPSLSPRA LMSLLFNASK AMDVLETALT MGLLDALEPG PVGLGDLATR FDVRPLRLYK
     FLDCLESVGV VEREEKSDDI TEASYRAVPG LRDAVRAVVG PGSLERDRDQ YPWRRLHGRL
     AESLRGEVSM TDDDFAWPPK TDEQTASFEQ SMSVGLGPVL EVFGRHADRL WSGRRRFLDV
     GGGDGTLAAR VLRDAPELRV DVYNLPAVGP LVEQTRTGCV APDRLGFVGG DFFAEPLPTG
     YDTISFVRVL HDWPNDVARM LVEKAYAALP PGGMLLICEE FRTPDRLAMQ FFWSYFLIGV
     DSCVSRLREV EFYTSLLTET GFEKIEVLPG GWELVVAHKP ER
//