ID A0A1C5BF56_9ACTN Unreviewed; 923 AA.
AC A0A1C5BF56;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Carbonic anhydrase {ECO:0000313|EMBL:SCF57081.1};
GN ORFNames=GA0115254_103884 {ECO:0000313|EMBL:SCF57081.1};
OS Streptomyces sp. Ncost-T10-10d.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF57081.1, ECO:0000313|Proteomes:UP000198750};
RN [1] {ECO:0000313|Proteomes:UP000198750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible hydration of carbon dioxide to form
CC bicarbonate. {ECO:0000256|ARBA:ARBA00024993}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the beta-class carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00006217}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FMDF01000033; SCF57081.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C5BF56; -.
DR OrthoDB; 9771198at2; -.
DR Proteomes; UP000198750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 3.40.1050.10; Carbonic anhydrase; 1.
DR InterPro; IPR001765; Carbonic_anhydrase.
DR InterPro; IPR036874; Carbonic_anhydrase_sf.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR PANTHER; PTHR11814:SF227; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF00484; Pro_CA; 1.
DR Pfam; PF00916; Sulfate_transp; 2.
DR SMART; SM00947; Pro_CA; 1.
DR SUPFAM; SSF53056; beta-carbonic anhydrase, cab; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198750};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..294
FT /note="SLC26A/SulP transporter"
FT /evidence="ECO:0000259|Pfam:PF00916"
FT DOMAIN 340..440
FT /note="SLC26A/SulP transporter"
FT /evidence="ECO:0000259|Pfam:PF00916"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 95056 MW; BFD5D7F2FD5BBC75 CRC64;
MSACVPTRHD HTSRSSRPPR DSGIKRPHSP PPPPHGGRFR ITGADLSASV TVFLLAVPMS
LGLAVAMDAP LEAGLISAAV GGIVAGLLGG TPLQVSGPSA GLTVVTAELI QIYGWRTTCA
ITIGAGLLQI LLGSLRAARS ALAVSPAIVH GTLAGIGVAI ALAQLHIVLG GSPQSSAVAN
ALALPDQWGR VSPAAPLIGA LTIAILTLWP RIPGRIGRVA RRIPAALAAV VTATVVAAIT
APGIARVDLP SWRSHALPEM PHGPVLALAT AVLTVMLVAS LESLLAAVAV DKLSADRAGG
QATARSKADL PSASSPASAS ASGRPGPACS SPPDPPVRRS DLDRELRAQG IANTLSGLVG
GLAVSGGAVR SSANVRAGAT GRASTVLHGV WVVLAAGLLV TALEQIPLAA LGALVMMVGI
QMVSFAHIRN VHKHREFLVY GATITGVLLF GVLKGVVIGI AVAVAVALHR LARTRIAVTE
QAGQHLVVVQ GQLTFLAVPR LSRALARLPQ DGDAVVELDG FFMDHAAYET IQDWSTAQTA
HGGRVVFTGR SGGRIAEPAS AAHSCCRPWT PWRNHHCHDR SGQTPETQHA RLDAGRAPDC
GSGAVEDGSP EHHTSHDASG AHSTPGPAGS PTAAPRRIGS NRLFSGLSSF QRNTAPLVRE
ELARLAREGQ RPSQLFITCA DSRLVTSMIT ASGPGDLFTV RNIGNLVPPP DAESSDDSVG
AAIEYAVDVL KVESITVCGH SGCGAMQALL GARPGPDTPL SSLWRWLRHG LPSLERMRSR
HHAWARISGR LPADAVEQLC LTNVVQQLDH LRAHGSVARR LAEGRLQLHG MYFHVGEAQA
YLLAEGASAG HALDEVFNRV DPGDAHASSG SHTPAEAHAL AGAHPPADSR SPAGSRSPGD
ADTPRPAAPG DPGGSGELER TGV
//
