ID A0A1C5BG16_9ACTN Unreviewed; 1003 AA.
AC A0A1C5BG16;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:SCF57367.1};
GN ORFNames=GA0115254_10402 {ECO:0000313|EMBL:SCF57367.1};
OS Streptomyces sp. Ncost-T10-10d.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF57367.1, ECO:0000313|Proteomes:UP000198750};
RN [1] {ECO:0000313|Proteomes:UP000198750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; FMDF01000035; SCF57367.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C5BG16; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000198750; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000198750}.
FT DOMAIN 515..593
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1003 AA; 110295 MW; 75BE9ADFADB5E63F CRC64;
MHDDRTLTEE RLDRALRERI RPAVHPRTAP LVFEVWHAPG EPVPFAEAVT APYKPGAIGD
DWGPAWGTSW FRVTGRVPAD WADETVEAVI DLGFARDRPG FSAEALAHRP DGSVVKALNP
RNTWLRIDEP VAGGEEFTYY LEAAANPEIL DGVSALGDRE TAGSEPLYRV ERMDVAVFDR
QVWELVQDLE VLDQLMRQLP LGSARRWEIL RAVERCLDSL DLDAVGASAT AAREQLRAVL
SSPAHASAHR LSAVGHAHID SAWLWPLRET VRKVARTTSN VVALMDDHPE FVFAMSQAQQ
LDWLREHQPA LYARVKEKAA AGQFVPVGGM WVESDTNMPG SEALARQFVY GKRFFLEEFG
VETEEVWLPD SFGYSAALPQ LVALSGSRWF LTQKISWNTT NPFPHHSFLW EGLDGTRVFT
HFPPVDTYVA ELSGEELAHA EKNFRDKGHA TRSLVPFGWG DGGGGPTREM LARAGRVADL
EGSPRVTIEK PADFFAAAEA EYDRPPVWLG ELYLELHRGT YTSQARTKQG NRRSEHLLRE
AELWAATATV RTGFPYPYEK LDRIWKSVLL HQFHDILPGS SIAWVHREAE ATYARSAGEL
EAVIDAAQRA LAGTAEDAGT IVFNSAPHDR AGVAAGGAAP APEQRERPVE AEAYGGGFRL
DNGLLRVTVD ARGLVVSVVD LVAGRETVAP GCAANLLQVH PDLPNRWDAW DVDAFYRNAV
TDLTGADVVR RSGDGIEVVR TFGSSRVTQL LTLRPGARRL DIDTEVDWHE QEKFLKAAFP
IDVRADHSTA ETQFGHVQRP THTNTSWEAA KFEICAHRFL HVGEPGWGAA LINDSTYGHD
VTRTVREDGS TTTTVRLSLL RAPRYPDPAT DQGVHRLRYA LLPGATIGDA VREGWQFSLP
ERRVPGSAAV APLVAVDDDA VVVTAVKLAD DGSGDVVVRL HEAHGGRVSA RLTAGFALAG
ASVTDLLERP LAGESTEVAG DSVRLRLRPF QIVTLRLTPN EEA
//