ID   A0A1C5BG16_9ACTN        Unreviewed;      1003 AA.
AC   A0A1C5BG16;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:SCF57367.1};
GN   ORFNames=GA0115254_10402 {ECO:0000313|EMBL:SCF57367.1};
OS   Streptomyces sp. Ncost-T10-10d.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF57367.1, ECO:0000313|Proteomes:UP000198750};
RN   [1] {ECO:0000313|Proteomes:UP000198750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; FMDF01000035; SCF57367.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5BG16; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000198750; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198750}.
FT   DOMAIN          515..593
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1003 AA;  110295 MW;  75BE9ADFADB5E63F CRC64;
     MHDDRTLTEE RLDRALRERI RPAVHPRTAP LVFEVWHAPG EPVPFAEAVT APYKPGAIGD
     DWGPAWGTSW FRVTGRVPAD WADETVEAVI DLGFARDRPG FSAEALAHRP DGSVVKALNP
     RNTWLRIDEP VAGGEEFTYY LEAAANPEIL DGVSALGDRE TAGSEPLYRV ERMDVAVFDR
     QVWELVQDLE VLDQLMRQLP LGSARRWEIL RAVERCLDSL DLDAVGASAT AAREQLRAVL
     SSPAHASAHR LSAVGHAHID SAWLWPLRET VRKVARTTSN VVALMDDHPE FVFAMSQAQQ
     LDWLREHQPA LYARVKEKAA AGQFVPVGGM WVESDTNMPG SEALARQFVY GKRFFLEEFG
     VETEEVWLPD SFGYSAALPQ LVALSGSRWF LTQKISWNTT NPFPHHSFLW EGLDGTRVFT
     HFPPVDTYVA ELSGEELAHA EKNFRDKGHA TRSLVPFGWG DGGGGPTREM LARAGRVADL
     EGSPRVTIEK PADFFAAAEA EYDRPPVWLG ELYLELHRGT YTSQARTKQG NRRSEHLLRE
     AELWAATATV RTGFPYPYEK LDRIWKSVLL HQFHDILPGS SIAWVHREAE ATYARSAGEL
     EAVIDAAQRA LAGTAEDAGT IVFNSAPHDR AGVAAGGAAP APEQRERPVE AEAYGGGFRL
     DNGLLRVTVD ARGLVVSVVD LVAGRETVAP GCAANLLQVH PDLPNRWDAW DVDAFYRNAV
     TDLTGADVVR RSGDGIEVVR TFGSSRVTQL LTLRPGARRL DIDTEVDWHE QEKFLKAAFP
     IDVRADHSTA ETQFGHVQRP THTNTSWEAA KFEICAHRFL HVGEPGWGAA LINDSTYGHD
     VTRTVREDGS TTTTVRLSLL RAPRYPDPAT DQGVHRLRYA LLPGATIGDA VREGWQFSLP
     ERRVPGSAAV APLVAVDDDA VVVTAVKLAD DGSGDVVVRL HEAHGGRVSA RLTAGFALAG
     ASVTDLLERP LAGESTEVAG DSVRLRLRPF QIVTLRLTPN EEA
//