ID   A0A1C5BLK6_9ACTN        Unreviewed;       531 AA.
AC   A0A1C5BLK6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II {ECO:0000313|EMBL:SCF59331.1};
GN   ORFNames=GA0115254_106155 {ECO:0000313|EMBL:SCF59331.1};
OS   Streptomyces sp. Ncost-T10-10d.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF59331.1, ECO:0000313|Proteomes:UP000198750};
RN   [1] {ECO:0000313|Proteomes:UP000198750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FMDF01000049; SCF59331.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5BLK6; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000198750; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:SCF59331.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198750}.
FT   DOMAIN          17..396
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          447..522
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   531 AA;  56333 MW;  D9AC6ABF9B78ADA4 CRC64;
     MSENEHPLTI PRALDLAARR YPGREAVVDG DVRLSWAQLC ERVHAAVKSL IALGVRPGDR
     IAVWAPNGHR WVIAALAATS AGAVLVPVNT RYKGAEARWL LERGGVRLLF VDNGFLGKDY
     LAMLGAGGEP GGDGPPVPGL PALESVVTLD GAERPGILPW DGFLHCGAHL PDTEATSRTG
     AVDPDDPCDL LFTSGTTGRP KGALTTHRQN LRTYWAWSGR TGVIGDDRYL VINPMFHCFG
     YKAGVLACLL RGATMVLQPV FDVDRAMRAV EAERITVLPG PPTIYSELLD APGRDGFDLS
     SLRLAVTGAA VVPVALVRRM RAELFPEVLT AYGLTETCGT VTVCSADDDA ETVALTAGRP
     LDGTEVRVAD DRGRALPAGQ DGRILVRGYH VMLGYLDDPA ASAAAVDAEG RLDTGDVGHF
     DARGNLVITG RSKDMFVVGG FNVYPAEVEQ VLTAHDAVAE AAVVGVPDAR LGEVGRAYVT
     VRPGAGTGPD DLVGHCRERL ANFKVPREVV VLETLPRSAT GKVDKAVLRT T
//