ID A0A1C5D8D4_9ACTN Unreviewed; 1135 AA.
AC A0A1C5D8D4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GA0115254_117224 {ECO:0000313|EMBL:SCF79228.1};
OS Streptomyces sp. Ncost-T10-10d.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF79228.1, ECO:0000313|Proteomes:UP000198750};
RN [1] {ECO:0000313|Proteomes:UP000198750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FMDF01000144; SCF79228.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C5D8D4; -.
DR Proteomes; UP000198750; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198750}.
FT DOMAIN 1..293
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 293..696
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 425..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 3..10
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1135 AA; 121558 MW; C5DB4E0B1D4F36E5 CRC64;
MLAGPGTGKT TTLVEAVAAR VARGGDPARI LVLTFSRKAA VELRDRMAAR LGAARGPQAT
TFHSFCYALV RAHQDADLFA EPMRLLSGPE QDVTVRELLA GQLELEQDGF AHIRWPDELR
ACLTTRGFAD EVRAVLARSR ELGLGPDALT DFARRTGRPD WGAAAEFLAE YLDVLDAQGV
LDYAELVHRA VLLAERPEVS ALLAGQYDAV FVDEYQDTDP AQVRLLHALA GNRGTAPGAG
GGRDLIAFGD PDQSIYAFRG ADVNGILDFP EMFRRADGAP APVGVLTASR RSGGQLLAAT
RLLTRRMPLT RLPSAKVRAH RELAAVREGG SVETYTYPTA SAELDNIADL LRRAHLEDGV
PWNEMAVLVR AGGRTIPSVR RALTSAGVPV EVDGDDLPLR HEPAVAPLLT ALRAVAAAAL
RRGAPGAEAG APASKGAETP DSEVREGAGA PASEGAGAPA SEGAGASASE GVEAQTPPGQ
EPDQAPGQDP EKAPGQGPEK APGREPVPEA PSWLDTETAL TLLTSPLGSM DAADLRRLGR
ALRDEERAAG NRVPAPSGDL LARALVEPER LVAHDPAYAR GAQRLGALLR KARELLEGGG
TAEEALWELW AGTPWPGRLE RAALRGGAGG RNADRDLDAV CALFDTAARA EERTGGRGAL
NFLEEVDAQD IAADTLSRRA VRPDAVRLMT AHRSKGLEWR LVVVAGVQEG LWPDLRRRGS
LLEADRIGRD GLAEPLTPGA LLAEERRLFY VAATRARERL VVTAVKAPAD DGDQPSRFLT
ELGVEPRDVT GRPRRPLAVA ALVAELRATT VDPDASDALR REAAHRLARL AALTDDEGQP
LVPAAHPYRW WGLYEPTRSA VPLRDRDQPV SLSGSALDQL ANTCALQWFL GREVKADAPA
TAAQGFGNVV HVLADEVASG RTPADLAVLM ERLDSVWDGL VFDAPWKSQQ EKEQARAALE
RFVRWHVMDR TGRTPAASEH DFDVTLEAGE YEVRIRGSMD RVEQDAEGRA YVVDFKTGKQ
SPTKDEVARH PQLAVYQLAV REGAVDEIFD GSRPVPGGAE LVQLRQPAPK KEGGDALPKV
QAQEPLSGEW VSDLLATAAG RVLDERFTPT TGQHCTHCTF RASCSAQPEG RHILE
//