ID   A0A1C5DQT4_9ACTN        Unreviewed;       877 AA.
AC   A0A1C5DQT4;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Glycine betaine/proline transport system substrate-binding protein {ECO:0000313|EMBL:SCF85353.1};
GN   ORFNames=GA0115254_119623 {ECO:0000313|EMBL:SCF85353.1};
OS   Streptomyces sp. Ncost-T10-10d.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF85353.1, ECO:0000313|Proteomes:UP000198750};
RN   [1] {ECO:0000313|Proteomes:UP000198750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363032};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363032}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000256|RuleBase:RU363032}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the OsmX family.
CC       {ECO:0000256|ARBA:ARBA00035642}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the binding-protein-
CC       dependent transport system permease family.
CC       {ECO:0000256|ARBA:ARBA00035652}.
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DR   EMBL; FMDF01000167; SCF85353.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5DQT4; -.
DR   OrthoDB; 9787902at2; -.
DR   Proteomes; UP000198750; Unassembled WGS sequence.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   CDD; cd13639; PBP2_OpuAC_like; 2.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; MetI-like; 1.
DR   InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   PANTHER; PTHR47737; GLYCINE BETAINE/PROLINE BETAINE TRANSPORT SYSTEM PERMEASE PROTEIN PROW; 1.
DR   PANTHER; PTHR47737:SF1; GLYCINE BETAINE_PROLINE BETAINE TRANSPORT SYSTEM PERMEASE PROTEIN PROW; 1.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF04069; OpuAC; 2.
DR   SUPFAM; SSF161098; MetI-like; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198750};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363032};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363032};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        50..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        90..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        134..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        201..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   DOMAIN          87..266
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50928"
SQ   SEQUENCE   877 AA;  96057 MW;  6E914BF32D56C005 CRC64;
     MFRLPLGDWV DSAVDWLQTH LSWLFDAISS IVSGMFDGIA AVLSAPAPLL FAGIVAVVAW
     WLRGLLAGVL AFVGFAVIDS VELWDEAMDT LTLVLVATII ALVLAVPLGI WASRSKTVSA
     VTRPVLDFMQ TMPAMVYLIP GVIFFGVGVV PGIIATIIFS LPPGVRMTEL GIRQVDAELV
     EAAEAFGTTR RNTLLRVQLP LALPTIMAGI NQVIMLGLSM VVIAGMVGGG GLGGAVYRAI
     GNVDVGLGFE AGISIVIVAM YLDRMTSALG REVSPLARRA LARAQSMAGG LKVWNHRPQP
     VVAVVGIVVL ALVAGGMGLF GSSGSDKATA ADGSKIGAGK KISMGYIPWD EGIASTYLWK
     EMLERQGFQV DVKQYEAGAL YTGMANGQID FETDSWLPVT HASYWKKYQD RLEDIGSWYG
     PTSLELAVPS YMKDVRSLDD LKGRSSQFKG RIVGIEPSAG EMGLLKDKIL PGYGLDKEYK
     VVDGSTPSML AELKRAYAKK EPIVVPLWSP HWAYNQFELT KLKDPKNLWG KGDGIHTLAR
     KGFSADNPEV GAWLKNFKMS EDQLTSLEAE IQKAGSGNEQ EAVRTWLKAN PGVAEKWTPV
     AKDKTSKNAG GKDERDRAVE MAWFPWEEDI AATYLWKAVL EERGYKINLK QFEVGPMYTA
     MSRGQIDVQF DGWLPYTQKN YWTKYGSQLT DIGSWYGPTS IEVAVPSYVK DVKSLADLKG
     KSSQFKGRIV GIEPGTATME NLKKNVLPAY GLDKEYKVVD SSTPGMLAEL KRAYAKKEPI
     AVLLWTPHWA YNEYGMTKLE DPEKAFGNGD RLHTIAGKDF PKQYPQLTKW FKNFKLSEDQ
     LAGLENQIQK RGTGHEEEAV KAWMEKNPGI ADKMAPQ
//