ID A0A1C5E1E6_9ACTN Unreviewed; 857 AA.
AC A0A1C5E1E6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Polynucleotide 3'-phosphatase /polynucleotide 5'-hydroxyl-kinase /polynucleotide 2',3'-cyclic phosphate phosphodiesterase {ECO:0000313|EMBL:SCF89219.1};
GN ORFNames=GA0115254_1216189 {ECO:0000313|EMBL:SCF89219.1};
OS Streptomyces sp. Ncost-T10-10d.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF89219.1, ECO:0000313|Proteomes:UP000198750};
RN [1] {ECO:0000313|Proteomes:UP000198750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FMDF01000182; SCF89219.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C5E1E6; -.
DR OrthoDB; 9807890at2; -.
DR Proteomes; UP000198750; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07423; MPP_Prp_like; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041780; MPP_PrpE-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR024028; PNKP_bac.
DR InterPro; IPR032380; PNKP_ligase_dom.
DR NCBIfam; TIGR04075; bacter_Pnkp; 1.
DR PANTHER; PTHR12435:SF2; PROTEIN KTI12 HOMOLOG; 1.
DR PANTHER; PTHR12435; UNCHARACTERIZED; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF16542; PNKP_ligase; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SCF89219.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198750};
KW Transferase {ECO:0000313|EMBL:SCF89219.1}.
FT DOMAIN 187..376
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 464..852
FT /note="Polynucleotide kinase-phosphatase ligase"
FT /evidence="ECO:0000259|Pfam:PF16542"
SQ SEQUENCE 857 AA; 94259 MW; 8607788BD1CEB610 CRC64;
MTSTSRTLPV TDLSLVVLIG ASGSGKSTFA RKHFKPTEIV SSDFCRGLVA DDENDQSASR
DAFDVLHYIV GKRLAAGRLT VVDATSVQSE SRKQLVQLAR SHDVLPIAIV LDLPEEVCIA
RNAARPDRAD MPRHVIQRHR RELRRSLRGL EREGFRKVHI LHTEEEAERA EVVLERRYND
LRHLTGPFDI IGDIHGCSSE LEALLGKLGY IDGTHPEGRT AVFVGDLVDR GPDSPGVLRR
VMSMVSAGNA LCVPGNHENK LGRYLKGRKV QHTHGLAETI EQLEREDEKD PAFREQVREF
IDGLVSHYVL DEGKLVVCHA GLPEKYHGRT SGRVRSHALY GDTTGETDEF GLPVRYPWAE
EYRGRAAVVY GHTPVPNTSW VNNTICLDTG AVFGGKMTAL RWPERELVDV PAEKVWYQPA
KPLTTEAPGG REGRPLDLAD VHGRRTVETR HMGRISVREE NAAAALEVMS RFAVDPRLLG
YLPPTMAPTA TSHEDGYLEH PAEAFAQYRA DGVTKVVCEE KHMGSRAVAL VCRDANTARE
RFGAGGTSHP SGGEGGPTGA LYTRTGRPFL DDVALTEVIL GRLRTAVTAA GLWEEWDTDW
VLLDAELMPW SLKAAGLLRS QYAAVGAASG AVFPEANAAL AAAVARGVDV GALADRQQGR
AADATAFTEA YRRYCWSTQG LDGVRLAPFQ ILAVQGRSLA SVPHDEQLAW LDRLVEHDPT
GLLQVTRRLV VDTGDEASVS SGIDWWLEMT GRGGEGMVVK PLAALVRDGK GRLVQPGIKV
RGREYLRIIY GPEYTRPENL ERLRGRFLGH KRSLALREYA LGLEALDRLA DGEPLWRVHE
AVFAVLALES EPVDPRL
//
