ID A0A1C5EE20_9ACTN Unreviewed; 1096 AA.
AC A0A1C5EE20;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Tricorn protease homolog {ECO:0000256|PIRNR:PIRNR036421};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR036421};
GN ORFNames=GA0115254_125914 {ECO:0000313|EMBL:SCF93479.1};
OS Streptomyces sp. Ncost-T10-10d.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF93479.1, ECO:0000313|Proteomes:UP000198750};
RN [1] {ECO:0000313|Proteomes:UP000198750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Degrades oligopeptides. {ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SIMILARITY: Belongs to the peptidase S41B family.
CC {ECO:0000256|ARBA:ARBA00008524, ECO:0000256|PIRNR:PIRNR036421}.
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DR EMBL; FMDF01000214; SCF93479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C5EE20; -.
DR OrthoDB; 9758793at2; -.
DR Proteomes; UP000198750; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd00988; PDZ_CTP_protease; 1.
DR CDD; cd07562; Peptidase_S41_TRI; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.750.44; -; 1.
DR Gene3D; 2.120.10.60; Tricorn protease N-terminal domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005151; Tail-specific_protease.
DR InterPro; IPR028204; Tricorn_C1.
DR InterPro; IPR029414; Tricorn_PDZ.
DR InterPro; IPR012393; Tricorn_protease.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43253; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR PANTHER; PTHR43253:SF1; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR Pfam; PF07676; PD40; 2.
DR Pfam; PF03572; Peptidase_S41; 1.
DR Pfam; PF14684; Tricorn_C1; 1.
DR Pfam; PF14685; Tricorn_PDZ; 1.
DR PIRSF; PIRSF036421; Tricorn_protease; 1.
DR SMART; SM00245; TSPc; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR036421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036421};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR036421};
KW Reference proteome {ECO:0000313|Proteomes:UP000198750};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|PIRNR:PIRNR036421}.
FT DOMAIN 854..1046
FT /note="Tail specific protease"
FT /evidence="ECO:0000259|SMART:SM00245"
FT ACT_SITE 754
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 977
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 1035
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT SITE 978
FT /note="Transition state stabilizer; via amide nitrogen"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-3"
SQ SEQUENCE 1096 AA; 118961 MW; 0EE1E0DA87B1E32E CRC64;
MSDDVAYLRF PHLHEDLLCF AAEDDLWVAP LAAEGQRPGR AWRLTVDRTR VSHPRFSPDG
SRIAFTTWRS LDPEIHLAPV EGGPARRLTY WGSTDARVCG WTPDPPDASQ ILAVSSHNQP
FSHVSWAYTV PTDGSPGGKL PWGPVSDIAV ADIDGERRTL LLTGKPPHEP ASWKRYRGGA
MGRLWLHGER LLPDIGGHLD SPMFVGGRIA FLSDHEGVGN LYSCLPDGSD LRRHTDHDAF
YARHASSDGS RIVYQCAGDV WLVDDLESPD AVSRKLEVRL GGPRAGRRTY QVSAASNVDS
LSVDETGRAS AVSVRGSLYW LTHRDGPART IADTPGVRVR LPEMLGSGGQ VAYVTDADGE
DAIEIAYLPR ASGDREPRRL ASGRIGRVHE LISDPDGERL AIATNDGRLL LLDTDEESTG
EPTELIRSVN GPVRDMAFSP DGAWLTWSHP GIGRSLRQIK LARILGSGAP VIVDVTNGRF
EDENPVFTGD GRYLAFLSWR GFDPVYDVHT GDLSFPLGCR PYLVPLSSAT PSPFALSPEG
RPAAGGLDPA DDVVVEAGTG EGPSTVTVEF EGLESRVTPF PVSASKYSAL RPVSGGGLVW
LRWPISGALG ETFANPADMS GRPTLEHFNI SKARKTELVG HLDWFAVSGD ATRLVVMDEG
ELRAVPATET GDSDSTVYID LRRILHEVDP GAEWRQAYGE GGRIIRAYFW EPDMCGIDWD
GVLDQYRPLV ERVASPDEFA DLMREVLGEL GTSHAYVAPA RRNEGPPHYQ RAIGLLGANL
VCRDGDWTIR RILPGDSSDS KARSPLAGTG IREGAVLTHV DGRPVDPVTG PYPLLAAAGG
TTVELTFRPS GGEGHSRRVA IVPLVDERPL RYQDWVAKRR EVVRELSGGK CGYLHIPDMG
GSGWAQFNRD LRGEVSRPAL IVDVRGNAGG HISELVVEKL TRTILGWDLT RNAQPVSYAS
NAPRGPVVAL ADEATSSDGD MITAVFRLLK LGPVVGQRTW GGVVGMTGRH RLGDGTVITV
PMNAAWFDAY GWSVENYGVE PDLEALRTPL DWAEGRYAVL DDGVRVALDL LAAHPAATPP
TYDDVPDRRR PPLPPR
//
