ID   A0A1C5ELN0_9ACTN        Unreviewed;       529 AA.
AC   A0A1C5ELN0;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Zn-dependent protease with chaperone function {ECO:0000313|EMBL:SCF96118.1};
GN   ORFNames=GA0115254_128013 {ECO:0000313|EMBL:SCF96118.1};
OS   Streptomyces sp. Ncost-T10-10d.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839774 {ECO:0000313|EMBL:SCF96118.1, ECO:0000313|Proteomes:UP000198750};
RN   [1] {ECO:0000313|Proteomes:UP000198750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ncost-T10-10d {ECO:0000313|Proteomes:UP000198750};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FMDF01000223; SCF96118.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5ELN0; -.
DR   OrthoDB; 155290at2; -.
DR   Proteomes; UP000198750; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07328; M48_Ste24p_like; 1.
DR   Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR   InterPro; IPR001915; Peptidase_M48.
DR   PANTHER; PTHR43221; PROTEASE HTPX; 1.
DR   PANTHER; PTHR43221:SF1; PROTEASE HTPX; 1.
DR   Pfam; PF01435; Peptidase_M48; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SCF96118.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198750};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          82..346
FT                   /note="Peptidase M48"
FT                   /evidence="ECO:0000259|Pfam:PF01435"
SQ   SEQUENCE   529 AA;  58601 MW;  2DC1B7E90965C6B8 CRC64;
     MSPTLRAVRA IALFAGFYLL GILLLSVLCV LDWAAFRWTW LPVAVMVLAR TSAPALPIVR
     GMFVLRIPRN DDVRGLHVDD TRQPRLWAMI RDLADRVGTR TPDDIVLTDQ VNASAVEDTR
     FLGLFAGRRR LLIGLPLMAG LSEAQLRSVL AHEMTRFANS DTRLTAINTR GRIQTTRTIT
     HFQEWVGKAV AMERARQEKK AAKALAKGKK AKKIDPSDAG TSLRRMAALY RRYANFSRRV
     TLSDTRCAQF AADDAAVRIA GRDVTASALL ETQVLLDMHE DYMDTYATLG VAAGMLPPPG
     QVLGGLRHVL AARKDELDEM RDSLPFEPSA PYAHPWVTER IARIEALPDD GRASEPVEPA
     LGLLVDTERT LAAAEEQVLT PQMLQLRRVD WPDLVHESMA TYGKWSAQKF GTVVAEVTGG
     DGTVTDTLDA LDAGAQWQIA DRLPKSDEAR AATGRAAREF ARPKLRDGLR QLVESEYVRQ
     GRARWRLSWI DNDTSLELPR GHEEMLPAAL DATVADVPDT KLLRALLIP
//