ID   A0A1C5H1Z9_9ACTN        Unreviewed;       709 AA.
AC   A0A1C5H1Z9;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SCG40040.1};
GN   ORFNames=GA0070613_0715 {ECO:0000313|EMBL:SCG40040.1};
OS   Micromonospora inositola.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=47865 {ECO:0000313|EMBL:SCG40040.1, ECO:0000313|Proteomes:UP000198221};
RN   [1] {ECO:0000313|EMBL:SCG40040.1, ECO:0000313|Proteomes:UP000198221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43819 {ECO:0000313|EMBL:SCG40040.1,
RC   ECO:0000313|Proteomes:UP000198221};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; LT607754; SCG40040.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5H1Z9; -.
DR   OrthoDB; 2365435at2; -.
DR   Proteomes; UP000198221; Chromosome i.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198221};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        315..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        376..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        522..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        580..598
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        619..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        653..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          169..334
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          548..678
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   709 AA;  73779 MW;  09746F68F310B5D8 CRC64;
     MTTRLQEKHR LAGLASGRRS KYAMLIFWLV LVAAAGPLAI KLTEVQDNDT LGALPATAEA
     SRAVQRAEDA FPDSQKPLAV AVYVRDGGLT GADRAKVDGD RTAFTRYADG GQVPPAIPSD
     DGQALLLSFP VAGDADQRAD AVADVKEQLG DAPAGLRTAL TGPAGGEDDV FDAFAGMDTT
     LLLATAATVA LLLLVTYRSP VLWLIPLITV AVANQLASAV VYLLARHAGL AVDLQSQSIL
     TVLVFGVGVD YALLLIARYR EELRRHADRH AAMAVALRRS IGAIGASAAT VAIGLLCLLA
     AHLPSTRGLG PVGAVGIAAA LLAMTTLLPA VLVIFGRWLF WPFVPRYSPD AVGLDVAAQH
     GVWRRIAGFV GRRPRAVWLG TAAALVALSF GIGNLSIGMP HDESFTKEVG SVTGQRMIEA
     HYPRGAVAPA EILAAAGPAD QVVAAARAVP GVAEVGEPQR SPDGRWVHIA AVLADTPDSD
     AALDTVDRLR DAVHAVPGAQ ALVGGDTAYL LDEERTVGRD NLVVVPLVLA VVFVILVLLL
     RALVAPLLLL ASVVLSYVAA MGAAGLILDA MGYPKLFVGI PLQTFLFLVA LGVDYTIFLT
     TRAREETARL GHRRGVLHAL TVTGGVITSA GVVLAATFGA LSVLPLVPSV QSAVIIGVGV
     LLDTFLVRSL LVPALALHVG PRVWWPSALA RPAIRPVAAP PVERAAAAS
//