ID   A0A1C5H4J6_9ACTN        Unreviewed;       628 AA.
AC   A0A1C5H4J6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase {ECO:0000256|ARBA:ARBA00012519};
DE            EC=2.7.7.70 {ECO:0000256|ARBA:ARBA00012519};
GN   ORFNames=GA0074704_1052 {ECO:0000313|EMBL:SCG40940.1};
OS   Micromonospora siamensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=299152 {ECO:0000313|EMBL:SCG40940.1, ECO:0000313|Proteomes:UP000198210};
RN   [1] {ECO:0000313|EMBL:SCG40940.1, ECO:0000313|Proteomes:UP000198210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45097 {ECO:0000313|EMBL:SCG40940.1,
RC   ECO:0000313|Proteomes:UP000198210};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-
CC         D-glycero-beta-D-manno-heptose + diphosphate; Xref=Rhea:RHEA:27465,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:59967, ChEBI:CHEBI:61593; EC=2.7.7.70;
CC         Evidence={ECO:0000256|ARBA:ARBA00000534};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004713}.
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DR   EMBL; LT607751; SCG40940.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5H4J6; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000198210; Chromosome i.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.20; -; 2.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR011914; RfaE_dom_II.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR   NCBIfam; TIGR02199; rfaE_dom_II; 1.
DR   PANTHER; PTHR43793:SF2; BIFUNCTIONAL PROTEIN HLDE; 1.
DR   PANTHER; PTHR43793; FAD SYNTHASE; 1.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   Pfam; PF00294; PfkB; 2.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198210};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          24..124
FT                   /note="Carbohydrate kinase PfkB"
FT                   /evidence="ECO:0000259|Pfam:PF00294"
FT   DOMAIN          342..424
FT                   /note="Carbohydrate kinase PfkB"
FT                   /evidence="ECO:0000259|Pfam:PF00294"
FT   DOMAIN          467..562
FT                   /note="Cytidyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01467"
FT   REGION          236..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  64541 MW;  31B6A37DA0CFC5AD CRC64;
     MAGAAAAEQR RLATVVESWL GRPVLVVGDA MLDEWRFAES ERLCREAPAP VLTLRRRISA
     AGGAANTAVN VAALGGRAVL VAPVGADVAG DELHDCLDRA GVWDRTVGQE GRPTPVKRRM
     LAGNQILLRE DSGDPDDPLD SDGVARLITA LECATEELRA AGGGVPPTLV VCDYGLGALP
     EVVRAWLVAN RDRYATVALD AHDLADWHGL SPTVVTPSFA EATRLLARAA VGFGSPPQAR
     PHLNHADAEP ADDGPSELIV GAAPGGAGER FVPDAGRYDP NGPWGAAAAG APTGEPTPAE
     SRVAMTGDGL SVTGTGVTVN AAAGDGVDRA VLAEARLAEL RAHTGADVVA VTLDTDGAVV
     GGAEGTPRRS HSTPVPASHA VGAGDAYLAA MTLALAADAA LPTAAQLAQL AATVTVSDTG
     TCVCRREDLL TALGDPGGDP DGPVLVDADE LATLVAEHRV AGRSVVFTNG CFDVLHPGHV
     RYLEQARALG DLLVVAVNSD GSVRRLKGPD RPVNPVEDRV TLLAALSCVD HVVVFEEDSP
     AALIEAVRPD VYVKGGDYPP EMVPEAPLVR RLGGQVRTLG YVPDRSTSAI IDRIRAAAHD
     GSPSAARDGS PAAARDGVTA PTTGRRRP
//