ID   A0A1C5H5I8_9ACTN        Unreviewed;       617 AA.
AC   A0A1C5H5I8;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SCG41306.1};
GN   ORFNames=GA0070614_0851 {ECO:0000313|EMBL:SCG41306.1};
OS   Micromonospora coxensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=356852 {ECO:0000313|EMBL:SCG41306.1, ECO:0000313|Proteomes:UP000198215};
RN   [1] {ECO:0000313|EMBL:SCG41306.1, ECO:0000313|Proteomes:UP000198215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45161 {ECO:0000313|EMBL:SCG41306.1,
RC   ECO:0000313|Proteomes:UP000198215};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
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DR   EMBL; LT607753; SCG41306.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5H5I8; -.
DR   OrthoDB; 9803111at2; -.
DR   Proteomes; UP000198215; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        23..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        56..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          297..568
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   617 AA;  66755 MW;  0F44056718B61AD0 CRC64;
     MDPAASRADS PPHRDWVTRR TKALSLLTLD TAAWCGGFLV AAWARYEFEL TPRQCVLALG
     AALVCAIVHA SIEQVRSTAR GRHPVGSAGE ARDLAGTAIL AAAVVLTALA TMPDRPVPAS
     VPVTGGAVAL LLMAAGRAGY RWRRDRDDRP ARSSDRALIY GVDAASERLV RVLTGDPQSR
     YLPVGLLDDD PDKQGLRLEG LRVLGGREQI EQAVRRTRAT TVIFSINGSD AELMRDVRGR
     TLQAGAAFKV LPPVRELLDR PVAVTDVRDL QITDLLGRAQ RVAELAFERN GLAGRRVLVT
     GAGGSIGSEL CRQIARCEPG ELMMLDRDES ALHALQMSLH GRALLDGPEL VLADIRDADG
     IARIIAERRP DVVFHAAALK HLTLLQRHPG EAIKTNVRGT LNVLEACRGV SEFVNISTDK
     AANPASVLGY SKRITERLTA HYATQVDGRF LSVRFGNVLS SRGSVLTAFQ AQVEAGLPIT
     VTHPDVTRYF MTVQEAVHLV LQAAVIGRGG EALVLDMGEP VRIADVARRL AAEAPTPTEI
     VFTGLRPGEK LHEDLFGTDE IDSRPLHPLI SHVRVPALAP EELHTLDPYA DADELIKRMA
     AYCEDLPTRV SILPSPR
//