ID A0A1C5IA16_9ACTN Unreviewed; 1064 AA.
AC A0A1C5IA16;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GA0070614_2478 {ECO:0000313|EMBL:SCG55240.1};
OS Micromonospora coxensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=356852 {ECO:0000313|EMBL:SCG55240.1, ECO:0000313|Proteomes:UP000198215};
RN [1] {ECO:0000313|EMBL:SCG55240.1, ECO:0000313|Proteomes:UP000198215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45161 {ECO:0000313|EMBL:SCG55240.1,
RC ECO:0000313|Proteomes:UP000198215};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LT607753; SCG55240.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C5IA16; -.
DR OrthoDB; 4349881at2; -.
DR Proteomes; UP000198215; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR PANTHER; PTHR44936:SF12; SENSOR PROTEIN CREC; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08376; NIT; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SCG55240.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:SCG55240.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 548..653
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 662..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..924
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..962
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1035
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 112121 MW; E486050FCD169050 CRC64;
MSTGPTTLPE IGDTADRDRG RRLPRLRDAR IRSKLALILV VPVAAVIALA TIRLVSTGEG
AVDATRLRSL TALSTDVSAL TQDLHKERMA AALYLANPQQ RVDDYNLRVR ATDQRITEYR
AERNGIGEVP DSVRDQLEVI DDHLETLNGT RQKVLDRRQM PVAEATLRYG IVLTDLVSYG
DTLAQLPGQE SLADARRAVA AFSRAKAAVA EEEAVAFTAL SGGRVDEEQF SAFVTTLTSQ
QEALVSFSLA AAPDQRDLVE GTVSGDAVGL ADRVAADITR SVGQQPLVTA GDAVASIGAV
NDLMRWAEIE LQDRLLRQAE DARNDVIRQA VVESVLVLLT LIIAVSLAVV LARSLNHSLR
RLREGALSVA NHDLPDAVKR LQNMGSVGDG GVEEIVRQVR DPIRLPNRDE VGQVALAFNV
VHREAVRVAA EQAALRTSVS AMFLNLARRS QTLVDRMIGE LDAIERSEED PKRLAQLFEL
DHLATRMRRN DENLLVLAGA DSAVPRRDDA LLVDVLRAAQ SEVELYNRIE FGTVDTDISV
AAHAVNDVVR LVAELLDNAT RFSPPTTTVV ADGRRIRDYV LIQVEDRGLG LTDEQLDSLN
RRLAAPPSVD VAAFRLMGLA VVSRLASRYG IRVELRRNVE GGTVAQVTLP NSAVVLPAHR
GRDSSLPRQR QPLAVEQTPL SSAGLGESAV GGRSGAATLT DSWRTTPPAP APWRPPVDAR
DAAPTVGFGA PVSAAPSSSV PTSAVPTSAV PTSAVPASAP PAEPSYGFSV GTPTVANPVL
DPLPKRAPAA EPAPALPLGP VAGASADPFA GSSASFAAPA VPYAAAPAAP AAPAAPAVPF
GGAPTPVAPA APYTPPAAAP AAPVVARPER PADSPIFREM EAVWFRSHGD DATAIFTRPD
FDGAPPEARQ DEAAPPPRPK LPTRVPSAPT AAGTPSVAPA APQPAATPPP SYAPPSVPTA
PPAPSATSSA GGADAWRTAA DEGWTRATKA AEPSTGGTTR SGLPKRVPQA QLVPGGIEPK
SGRDRSRRTP DEVRGLLSAY HRGVQRGRSA GTDQNSTSTK ETRR
//
