ID   A0A1C5J2S9_9ACTN        Unreviewed;       376 AA.
AC   A0A1C5J2S9;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Signal transduction histidine kinase {ECO:0000313|EMBL:SCG64874.1};
GN   ORFNames=GA0070609_4002 {ECO:0000313|EMBL:SCG64874.1};
OS   Micromonospora echinaurantiaca.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=47857 {ECO:0000313|EMBL:SCG64874.1, ECO:0000313|Proteomes:UP000198217};
RN   [1] {ECO:0000313|EMBL:SCG64874.1, ECO:0000313|Proteomes:UP000198217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43904 {ECO:0000313|EMBL:SCG64874.1,
RC   ECO:0000313|Proteomes:UP000198217};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; LT607750; SCG64874.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5J2S9; -.
DR   Proteomes; UP000198217; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR   Gene3D; 1.20.5.1930; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR   PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SCG64874.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198217};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        43..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        74..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          178..244
FT                   /note="Signal transduction histidine kinase subgroup 3
FT                   dimerisation and phosphoacceptor"
FT                   /evidence="ECO:0000259|Pfam:PF07730"
FT   DOMAIN          288..373
FT                   /note="Histidine kinase/HSP90-like ATPase"
FT                   /evidence="ECO:0000259|Pfam:PF02518"
SQ   SEQUENCE   376 AA;  39496 MW;  B01C8EB842BAD27D CRC64;
     MRRDLPYALG GLALGGLLLG NATLAPDAAP VRAVDVALVL LMAAALAVCR RFPVVALAVV
     TAAMLALHVR VHPGAAASFP VLGAVYVAAW RGHRAPAVLA SLVFLGVFLA RDVSVAPTDR
     PGQLIVERTS LLLGWFVAAN VAGLVAGQRR AYLEQVEQRA IEAERTREEM ALRRAGEERL
     RIARDLHDSL THNISVIKVQ AGIAVHLARK HHEEPSAALL AIQEASGAAM RELRATLDVL
     RSPADGDRVG LARVDELAER TRAAGVPVRV TVTGPPRELP AEVDQAGYRV VQEALTNVAR
     HAGPATAQVH IDYAPAQLTV AVDDDGQASP DRPVTPGVGL RGMTERVTGL GGTLRAAARD
     GGGFAVRATF PLDGPA
//