ID A0A1C5JKR8_9ACTN Unreviewed; 526 AA.
AC A0A1C5JKR8;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Sodium/proton antiporter, CPA1 family {ECO:0000313|EMBL:SCG71108.1};
GN ORFNames=GA0070213_111234 {ECO:0000313|EMBL:SCG71108.1};
OS Micromonospora humi.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=745366 {ECO:0000313|EMBL:SCG71108.1, ECO:0000313|Proteomes:UP000199360};
RN [1] {ECO:0000313|EMBL:SCG71108.1, ECO:0000313|Proteomes:UP000199360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45647 {ECO:0000313|EMBL:SCG71108.1,
RC ECO:0000313|Proteomes:UP000199360};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR EMBL; FMDM01000011; SCG71108.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C5JKR8; -.
DR STRING; 745366.GA0070213_111234; -.
DR OrthoDB; 57886at2; -.
DR Proteomes; UP000199360; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM/HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 83..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 155..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 217..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 342..367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 8..404
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 526 AA; 56025 MW; EA48560722A7ACC9 CRC64;
MEALFEVVVI LAIATFGAAL ARRLGLLAPI LLVVLGLALS FLPFFPHVRL DPDLVLVGIL
PPLLYVAAVN TSVPAFRLNL RPILLLAVGL VIFTAFVVGT VVHLFLPDLP YAICVALGAV
VAPPDAVAAT AVARRVGLPR RIVTILEGES LVNDATALVL LRVAIVAATA STGGVGVGEV
AREVLVAAGG GILVGLLGVV VFGYLHKLIT DPVLDNALSL IVPFAVVFAA EEIHASGVVA
VVVTGLGIGH KLPMLMSAGS RLQVTAFWRL IQFLLEGLVF LLVGLQLPEV VRDLDEPVGS
LVAITVGVLA AVFLARFVWM FPATYLARLV PRVRQRDPAP PVQIPVVISW AGMRGVVTLA
AALGLPLTLA DDRPYPRALL IWLAFAVIVA TLVGQGATLP WLARKLRLPP DDPVQDALSA
AGVQQRASRA ALDRLDAMAD EAPPAVVERL RGLTASRANL AWERLGGTDR ETPSQAYARL
RQEMIDAERE VFRAARDSGQ IPEEVLTRAY RDLDLEESLL RQEVLE
//