GenomeNet

Database: UniProt
Entry: A0A1C5JKR8_9ACTN
LinkDB: A0A1C5JKR8_9ACTN
Original site: A0A1C5JKR8_9ACTN 
ID   A0A1C5JKR8_9ACTN        Unreviewed;       526 AA.
AC   A0A1C5JKR8;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Sodium/proton antiporter, CPA1 family {ECO:0000313|EMBL:SCG71108.1};
GN   ORFNames=GA0070213_111234 {ECO:0000313|EMBL:SCG71108.1};
OS   Micromonospora humi.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=745366 {ECO:0000313|EMBL:SCG71108.1, ECO:0000313|Proteomes:UP000199360};
RN   [1] {ECO:0000313|EMBL:SCG71108.1, ECO:0000313|Proteomes:UP000199360}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45647 {ECO:0000313|EMBL:SCG71108.1,
RC   ECO:0000313|Proteomes:UP000199360};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU366002}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FMDM01000011; SCG71108.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5JKR8; -.
DR   STRING; 745366.GA0070213_111234; -.
DR   OrthoDB; 57886at2; -.
DR   Proteomes; UP000199360; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   NCBIfam; TIGR00831; a_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF86; SODIUM/HYDROGEN EXCHANGER 7; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU366002};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM        24..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        54..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        83..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        155..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        184..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        217..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        299..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        342..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        379..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   DOMAIN          8..404
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   526 AA;  56025 MW;  EA48560722A7ACC9 CRC64;
     MEALFEVVVI LAIATFGAAL ARRLGLLAPI LLVVLGLALS FLPFFPHVRL DPDLVLVGIL
     PPLLYVAAVN TSVPAFRLNL RPILLLAVGL VIFTAFVVGT VVHLFLPDLP YAICVALGAV
     VAPPDAVAAT AVARRVGLPR RIVTILEGES LVNDATALVL LRVAIVAATA STGGVGVGEV
     AREVLVAAGG GILVGLLGVV VFGYLHKLIT DPVLDNALSL IVPFAVVFAA EEIHASGVVA
     VVVTGLGIGH KLPMLMSAGS RLQVTAFWRL IQFLLEGLVF LLVGLQLPEV VRDLDEPVGS
     LVAITVGVLA AVFLARFVWM FPATYLARLV PRVRQRDPAP PVQIPVVISW AGMRGVVTLA
     AALGLPLTLA DDRPYPRALL IWLAFAVIVA TLVGQGATLP WLARKLRLPP DDPVQDALSA
     AGVQQRASRA ALDRLDAMAD EAPPAVVERL RGLTASRANL AWERLGGTDR ETPSQAYARL
     RQEMIDAERE VFRAARDSGQ IPEEVLTRAY RDLDLEESLL RQEVLE
//
DBGET integrated database retrieval system