ID   A0A1C5KA25_9ACTN        Unreviewed;       624 AA.
AC   A0A1C5KA25;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Serine protease, subtilisin family {ECO:0000313|EMBL:SCG79510.1};
GN   ORFNames=GA0070609_5922 {ECO:0000313|EMBL:SCG79510.1};
OS   Micromonospora echinaurantiaca.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=47857 {ECO:0000313|EMBL:SCG79510.1, ECO:0000313|Proteomes:UP000198217};
RN   [1] {ECO:0000313|EMBL:SCG79510.1, ECO:0000313|Proteomes:UP000198217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43904 {ECO:0000313|EMBL:SCG79510.1,
RC   ECO:0000313|Proteomes:UP000198217};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; LT607750; SCG79510.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C5KA25; -.
DR   Proteomes; UP000198217; Chromosome i.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000198217};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..624
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008720358"
FT   DOMAIN          502..624
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   ACT_SITE        156
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        188
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        345
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   624 AA;  62273 MW;  407E4C630437288B CRC64;
     MALPHRSVLV GVAALAMVAA ATPAMAAEPV GVIRSAGGDT AVADSYIVVF KDSAVGRSAV
     GDNAQRLVGR HGGTVARTYG AALRGFEVRV GAKAAARIAA DPAVAYVEQN HTVTISGTQT
     NPPSWGLDRI DQRNLPLNNS YTYPNTASNV RAYVIDTGVL YGHNDFGGRA VSGFDAVDGG
     SADDCNGHGT HVAGTVGGSA YGVAKGVQIV GVRVLNCQGS GTNAQVVAGI DWVTANAVKP
     AVANMSLGGG ANSSIDTAVT NSINSGITYA VAAGNGDIFG NRQNACNYSP ARVASAITVG
     ATQNNDAAAS FSNYGTCVDI LAPGVNITSA WYTGNSATNT ISGTSMASPH VAGAAALVLS
     ANPSWSPQQV RDSLVNNATP NVVTNPGTGT PNRLLYVVND GTPPVNDFSV SVSPTSGSTA
     PGGSVTTTVG TATTNGSAQS VSLSASGLPS GATASFNPAT VTSGGSSTLT ISTSASTPPG
     TYPVTVTGSA ASGTRTATYT LTVTGSGGGG CSGSNGTDVA IPDTGATVSS SITIAGCARN
     ASSSSTVAVN IVHTYRGDLV VDLVAPDGSS YRLKNSSFWD GADNINTTYT VNLSSEAANG
     TWQLRVRDVY AGDTGYINTW TLTL
//