ID A0A1C6LGT5_9ACTN Unreviewed; 315 AA.
AC A0A1C6LGT5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=23S rRNA (Guanosine2251-2'-O)-methyltransferase {ECO:0000313|EMBL:SCK05744.1};
GN ORFNames=H180DRAFT_00104 {ECO:0000313|EMBL:SCK05744.1};
OS Streptomyces sp. WMMB 322.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1286821 {ECO:0000313|EMBL:SCK05744.1, ECO:0000313|Proteomes:UP000182082};
RN [1] {ECO:0000313|EMBL:SCK05744.1, ECO:0000313|Proteomes:UP000182082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMMB 322 {ECO:0000313|EMBL:SCK05744.1,
RC ECO:0000313|Proteomes:UP000182082};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR EMBL; FMHI01000001; SCK05744.1; -; Genomic_DNA.
DR RefSeq; WP_055483963.1; NZ_FMHI01000001.1.
DR AlphaFoldDB; A0A1C6LGT5; -.
DR STRING; 1286821.GCA_001418285_00104; -.
DR OrthoDB; 9785673at2; -.
DR Proteomes; UP000182082; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18103; SpoU-like_RlmB; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR NCBIfam; TIGR00186; rRNA_methyl_3; 1.
DR PANTHER; PTHR46429; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR PANTHER; PTHR46429:SF1; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:SCK05744.1};
KW Transferase {ECO:0000313|EMBL:SCK05744.1}.
FT DOMAIN 73..150
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 32995 MW; 59EE2DCB2C5F07D3 CRC64;
MAGNSQRPNR RTSNKKGAQV GSGGKRRRGL EGKGPTPPAE MRKGHAKQRA AQAKARRSQG
RARKAGGKSA SELVVGRNSV VEALRERVPA STLYVQQFIE NDDRVREAVR LAGEAGGINL
MEAPRPELDR MTKGLHHQGL VLQVPEYEYA HPDDLAAAAY DEGEDPLIVA LDGITDPRNL
GAVVRSVSAF GGHGVVVPER RAAGMTAGAW KTSAGTAAHT PVARAANLTR ALESYQKAGM
MVVGLAADGD VGLPDLDALD GPVVVVVGSE GKGLSRLVGE TCDVRVRIPM PGGAESLNAG
VAAGVVLYEA ARRRS
//
