ID A0A1C6N6W1_9ACTN Unreviewed; 388 AA.
AC A0A1C6N6W1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:SCK26651.1};
GN ORFNames=H180DRAFT_02043 {ECO:0000313|EMBL:SCK26651.1};
OS Streptomyces sp. WMMB 322.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1286821 {ECO:0000313|EMBL:SCK26651.1, ECO:0000313|Proteomes:UP000182082};
RN [1] {ECO:0000313|EMBL:SCK26651.1, ECO:0000313|Proteomes:UP000182082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMMB 322 {ECO:0000313|EMBL:SCK26651.1,
RC ECO:0000313|Proteomes:UP000182082};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; FMHI01000005; SCK26651.1; -; Genomic_DNA.
DR RefSeq; WP_055485716.1; NZ_FMHI01000005.1.
DR AlphaFoldDB; A0A1C6N6W1; -.
DR STRING; 1286821.GCA_001418285_02034; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000182082; Unassembled WGS sequence.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2}.
FT MOD_RES 208
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 388 AA; 40944 MW; 60386AD0CC84E65F CRC64;
MSDQRDSGHT PQSFETLAIH AGQTADPATG AVVPPIYQVS TYKQDGVGGL RGGYEYSRSA
NPTRTALEQN LAALEGGRNA FAFASGLAAE DCLLRTLLVP GDHVVVPNDA YGGTFRLFSR
VAERWGVEWS VADTSDPAAV RAALRDRTKA VWVETPSNPL LGISDITALA QLAHGAGARL
VVDNTFASPY LQQPLALGAD VVVHSTTKYM GGHSDVVGGA LVLDESELAA EIAFHQNAMG
AVAGPFDSWL VMRGTKTLAV RMERHSANAS RVAEMLQAHP RVTQVYYPGL PSHPGHETAA
KQMRAFGGMV SFRVADGEEA AVQVCNRAQL FTLGESLGGV ESLIEHPARM THASAAGSAL
EVPADLVRLS VGIESVEDLL ADLQQALG
//
