ID A0A1C6NGR1_9NEIS Unreviewed; 337 AA.
AC A0A1C6NGR1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:SCK29957.1};
GN ORFNames=PSELUDRAFT_3708 {ECO:0000313|EMBL:SCK29957.1};
OS Vogesella sp. LIG4.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC Chromobacteriaceae; Vogesella.
OX NCBI_TaxID=1192162 {ECO:0000313|EMBL:SCK29957.1, ECO:0000313|Proteomes:UP000198213};
RN [1] {ECO:0000313|EMBL:SCK29957.1, ECO:0000313|Proteomes:UP000198213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LIG4 {ECO:0000313|Proteomes:UP000198213};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00010584}.
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DR EMBL; LT607802; SCK29957.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6NGR1; -.
DR OrthoDB; 9805684at2; -.
DR Proteomes; UP000198213; Chromosome i.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR PANTHER; PTHR46278:SF2; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46278; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000198213}.
FT DOMAIN 6..121
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 132
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 244
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 337 AA; 35925 MW; 5C5A077BE0162030 CRC64;
MSEAIRVAVV GATNLVGQAV LELLAERELP IERVYALDVA DKEGESAYYG NLELDVLAVE
EFDFANVALV IFVAGTALSR QYVQAARAAG AAVVDFSAAY RQADDVPLYA PRINDKQLDD
LGEAPLVSIP NCTVTPLAQA LATLQAAGLQ RVSVTTFQSV SGSGQAALEE LASQTTALFS
QRDAEMEVFP KRIAFNVLPL IGSVDEQGVS EEELSVEQEV RKLLAQPALV IEASCVRVPV
FFGHGWAVSV ESADALSADK ARELFAAAGL QVVDDPAGDM PYVTPLEASG NEAVWVSRVR
RQGRALQFWL AADNIRAAIA HNCVATAAAL MKRGYFA
//
