ID   A0A1C6NK03_9ACTN        Unreviewed;       890 AA.
AC   A0A1C6NK03;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Phenyloxazoline synthase MbtB {ECO:0000256|ARBA:ARBA00016743};
DE   AltName: Full=Mycobactin synthetase protein B {ECO:0000256|ARBA:ARBA00033440};
GN   ORFNames=H181DRAFT_02495 {ECO:0000313|EMBL:SCK31543.1};
OS   Streptomyces sp. WMMB 714.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1286822 {ECO:0000313|EMBL:SCK31543.1, ECO:0000313|Proteomes:UP000182206};
RN   [1] {ECO:0000313|Proteomes:UP000182206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WMMB 714 {ECO:0000313|Proteomes:UP000182206};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005102}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       MbtB subfamily. {ECO:0000256|ARBA:ARBA00007380}.
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DR   EMBL; FMHJ01000006; SCK31543.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6NK03; -.
DR   STRING; 1286822.GCA_000964305_02483; -.
DR   Proteomes; UP000182206; Unassembled WGS sequence.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   PANTHER; PTHR45527:SF10; PHENYLOXAZOLINE SYNTHASE MBTB; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
PE   3: Inferred from homology;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182206}.
FT   DOMAIN          11..82
FT                   /note="Polyketide synthase phosphopantetheine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00823"
FT   REGION          82..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          796..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          864..890
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   890 AA;  91859 MW;  7B27BAED13655817 CRC64;
     MTSPSPADSP TALLAGELAA VLGVDAQQID TGRPLTELGL EPGSATLLRH RLRAYGDADL
     SVRRLLGGGS VRTLGALLAR ADSPPAAAPS SSPAAPAADP PVPLPGDLLA RFTSRAEAAE
     LTREEALFAA VVLAAARWTC GTGGLGVEAE QPSAGTARVP VPDLLRWEGF AAYARELRSA
     APAPSAALRS GGSAVRFRLD AGGGAVLGLV LDLDGPRPGA RWESRGATGT PGDAPLATGL
     GAAFGRLLSV LAGDPEAWLR PDLGWDPTFA FQEPLTVRPF PDAGPLLDGP LRAAAVRTPH
     APALLGPSDA LTHGELAARA AHVAGLLREA GVRRGSSVAV ALPKGFEQIA AVTGVARHGA
     VYVPVDVSWP GTRIAAVCRR AGIGHALVPA GGSAELPADV VPLVLDEGTA GEGDVPSAAE
     AGAPRADPDS PAYTIFTSGS TGEPKGVVVD HAAARVTVDD ITDRLAIGPD DRVLGLSALS
     FDLSVYDVFG VLGAGGALVL PEPGGEQDPQ HWMDLIERHR VTFWNTAPAL MQMLLDLADA
     DPAAAARQLA SLRCVLLSGD WIPVTLPDRL RALVPGVRVV SAGGATEAAI WSICYPVGTV
     PAHWRSIPYG RPLRGQFFHV LDDEGRPLPV GQEGELHIAG RGLARGYAGD EAQTAARFPV
     HEKLGERVYR TGDMGMWRTD GTIEFMGRKD RQVKIRGHRI ELGEIESVLD RLPAVRRAVA
     SVVRESDGRP RLTAHVALRP EALARGTRLV RGELLDALRQ SVPSYMVPQS LVLTDALPVT
     ANGKVDHARL ASLEETATGA DGGTGAGPAA GDGGQTPRAA LADAVADALR RGLAVRISVT
     PGPGQDAAEV REWAGALRRD STFAVEAGSP AEGSGATLTS RPGPAPTGVR
//