ID A0A1C6PYP1_9ACTN Unreviewed; 733 AA.
AC A0A1C6PYP1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:SCK48474.1};
GN ORFNames=H181DRAFT_04354 {ECO:0000313|EMBL:SCK48474.1};
OS Streptomyces sp. WMMB 714.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1286822 {ECO:0000313|EMBL:SCK48474.1, ECO:0000313|Proteomes:UP000182206};
RN [1] {ECO:0000313|Proteomes:UP000182206}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMMB 714 {ECO:0000313|Proteomes:UP000182206};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FMHJ01000012; SCK48474.1; -; Genomic_DNA.
DR RefSeq; WP_045866225.1; NZ_FMHJ01000012.1.
DR AlphaFoldDB; A0A1C6PYP1; -.
DR STRING; 1286822.GCA_000964305_04331; -.
DR Proteomes; UP000182206; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SCK48474.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000182206};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SCK48474.1}.
FT DOMAIN 67..164
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 405..474
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 654..728
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 78659 MW; 13DAC4CB7669543C CRC64;
MRSLRRLSHA ALLGQGPRRD GLPDAMEHVA KVHRAHHPEA DLAALRRAYV LAESSHRGQM
RKSGDPYITH PLAVTLLLAQ LGAETTTLTA SLLHDTVEDT DVTLNQVREE FGEEVSYLVD
GVTKLEKVDY GAAAEPETFR KMLVATGNDV RVMSIKLADR LHNMRTLGVM RPEKQVRIAK
VTRDVLIPLA ERLGVQALKT ELEDLVFAIL HPEEHALARE LIAEHAKEPD PLTGMATSVR
RVLREAGIIA QVLIRPRHTV SVHRLRQKRG ELGPCDFGRL LIMVEEDADC YAVLGELHTC
FTPIVAEFKD FIAAPKFNLY QSLHTAIADE EGRVAEVLVR TRQMHRVAEA GVIALGDPHG
VPSGGDGSDT EPGPGWLSRL LKWQSHATDT ETFWTELRDE LAQDREITVY CASPGAAPAP
SGGALPLPAG ATCVDAAYAR YGEAAHRCIG ARVNGRLTAL STVLRDGDAL QLFLEPAASA
PSGPSPEWLD HARTPAARIA IRHWLAAHPV AAEAEPKQEL TSVGATGNGG GHARQAGDGG
SRAVAPCSTA APVSPPDPAD PGGRSSREDS TGPSPDSGRA TETASVVAED PHAVVRLARC
CTPVPPDSVT GFAVRGGAVT VHRESCQTVT RMASTGRRPV PVSWRQGAAG CRVTLRAEAL
GRPHLLADLT EIIAAQGAAV VAADVEPPRE QRVLHTYTLQ LPDAAGLPDL MRAMRRVPGV
YDVTRASRPL PAR
//
