ID A0A1C6R2N1_9BURK Unreviewed; 971 AA.
AC A0A1C6R2N1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=VAR608DRAFT_7350 {ECO:0000313|EMBL:SCK62094.1};
OS Variovorax sp. HW608.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=1034889 {ECO:0000313|EMBL:SCK62094.1, ECO:0000313|Proteomes:UP000198203};
RN [1] {ECO:0000313|Proteomes:UP000198203}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HW608 {ECO:0000313|Proteomes:UP000198203};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; LT607803; SCK62094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6R2N1; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000198203; Chromosome i.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd10567; SWIB-MDM2_like; 1.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR019835; SWIB_domain.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF02201; SWIB; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 2.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00151; SWIB; 1.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SCK62094.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 2..144
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 895..971
FT /note="DM2"
FT /evidence="ECO:0000259|PROSITE:PS51925"
FT REGION 245..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 108042 MW; 6D9B61A55DA2ED1E CRC64;
MKTLVIAEKP SVAQDIVRAL TPVAGKFDKH EEHFENEKYV VTSAVGHLVE IQAPEEFDVK
RGKWSFANLP VIPPRFDLKP VDKTKTRLAA VVRQAKRKDV TELVNACDAG REGELIFRLI
EQYAGGKSSL GKPVRRLWLQ SMTPQAIRDG FDQLRSDQQM KGLADAARSR SEADWLVGIN
GTRAMTAFNS RDGGFFLTTV GRVQTPTLSV VVEREEKIRK FVSRDYWEVH GTFLAEAGEY
PGKWFDPEWK KPPPGPDGAP DPEQRADRVW SEREALAIAE AARGKVASVT EESKPTTQAS
PLLFDLTSLQ REANSRFGYS AKTTLALAQS LYERHKALTY PRTDSRALPE DYLPVVRQTM
GMLAGSGMRH LAPFAQQAID GNYVKPSKRI FDNAKVSDHF AIIPTLQAPS GLSEAEQRLY
DFVVRRFLSV FFPSAEYQVT TRISTVEHAG RKYPFRSDGK VLVKPGWLAI YGKEAQDEEK
EDDKDGKRLV PVKPGEKVKV QSADIKGLKT RPPARYSEAT LLGAMEGAGK TIDDDELRAA
MHEKGLGTPA TRAAIIEGLL TEKYIHREGR ELIPTAKAFQ LMTLLRGLGV EELSKAELTG
EWEYKLAQME HGKLSREAFM REIAEMTQHI VKKAKEYDRD TVPGDYVTLK TPCPNCGGVV
KENYRRYSCT GKLGQEPCGF SFGKSPAGRT FEFEEADQLL RNKHIGPLDG FRSKAGWPFT
SEIVLRYDDE AKNWKLEFDF GDDKNAETGE IVDFTGQESL GPCPKCGARV FEYGSNYVCE
RSVPTHEHPK PTCDFKTGKI ILQQPVDRAQ AEKLLSTGKT DLLDKFVSTR TRRAFKAFLT
WNKDEGKVTF EFEPRTSKFP PRKTFAKAAP AAAKKAAPAK KVAAKKAAAP KAPRKPAAGL
KPSDALAAVI GTEPVPRTEV IKKLWDYIKA NGLQDATNKR AINADAKLKP VFGKDQVTMF
ELAGIVGKHL S
//
