ID   A0A1C6RNK2_9ACTN        Unreviewed;       749 AA.
AC   A0A1C6RNK2;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SCL18715.1};
GN   ORFNames=GA0070616_1574 {ECO:0000313|EMBL:SCL18715.1};
OS   Micromonospora nigra.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=145857 {ECO:0000313|EMBL:SCL18715.1, ECO:0000313|Proteomes:UP000199699};
RN   [1] {ECO:0000313|EMBL:SCL18715.1, ECO:0000313|Proteomes:UP000199699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43818 {ECO:0000313|EMBL:SCL18715.1,
RC   ECO:0000313|Proteomes:UP000199699};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FMHT01000003; SCL18715.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6RNK2; -.
DR   STRING; 145857.GA0070616_1574; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000199699; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199699};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        268..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        389..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        544..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        611..632
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        659..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        689..712
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          194..326
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          546..711
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          342..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  76857 MW;  EE25496FE3002BA5 CRC64;
     MATLLYRLGR GSMRRRRLVA VLWLVVLVGL GLAAATLRGP TASNFTMPGT ESQRALDLLA
     EQFPAASGAT GTIAVKAPAD GQLGTPEGQA VVQGIIAEAA ALPGVVGAVD PFQVGAISPN
     ARYALVQVQF AGGADELTDE QRDAYEEIGG QAESQGWQVA PGGEVLNTEP EVGSTEAIGV
     AVALLVLVVT FGSLVAAGMT MLNALIGVGV GMAGLFTLSS VVELTSTAPI LALMLGLAVG
     IDYSLFITSR YRQNLLEGLP ADEAVGRAVG TAGSAVTFAG ATVVIALAGL AVVNIPFLTV
     MGLAAAGTVT VAVLVALTLQ PALLGFAGRR VLSRKRRDAA FAPAAPAQTT QTAPEQATPE
     QATPASADAA PAEDRSAFGF RWARLVTRFR VPVILVGLLG LGLLALPAPD MRLALPDAGT
     APVGSPARES HDLITEGFGP GFTGRLAVVV AGDDAQATAA AVPQVAALVQ GTENVLAVAP
     PQLSPDGRTA LLGVIPRTGP TEPATETLVN DIRDSVGGIQ NAEVLLTGVT AIGIDVSEKL
     SDALPVYLLL VVGLSVLLLM LVFRSLLVPV KAALGFLLTV AATFGITVAV FQEGTLAGLV
     GLDTPGPLIS FLPILLIGIL FGLAMDYEVF LVSRMREDFV HGDTAQQATI NGMGHGARVV
     TAAALIMISV FGGFVFLDDP VIKSMGFALA IGVAIDAFVV RMTIVPAVMS LLGAKAWWLP
     RWLDRALPNV DIEGEGLRNH LGEKTPANV
//