ID   A0A1C6RY11_9ACTN        Unreviewed;       488 AA.
AC   A0A1C6RY11;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating) {ECO:0000313|EMBL:SCL21964.1};
GN   ORFNames=GA0070624_2433 {ECO:0000313|EMBL:SCL21964.1};
OS   Micromonospora rhizosphaerae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=568872 {ECO:0000313|EMBL:SCL21964.1, ECO:0000313|Proteomes:UP000199413};
RN   [1] {ECO:0000313|Proteomes:UP000199413}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45431 {ECO:0000313|Proteomes:UP000199413};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   EMBL; FMHV01000002; SCL21964.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6RY11; -.
DR   STRING; 568872.GA0070624_2433; -.
DR   OrthoDB; 9805787at2; -.
DR   Proteomes; UP000199413; Unassembled WGS sequence.
DR   GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199413}.
FT   DOMAIN          95..228
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          240..462
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
FT   REGION          463..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  50776 MW;  0B4A6875934AF13B CRC64;
     MAITRLPSAG FSITIRIAMP ADASSIGRLT TSVGEAGAIV TALDVVDSDP THVIVDLTCD
     TADASHADQV VKALTALEGV DVRKVSDRTF LLHLGGKIEV SSKVALRTRD ELSRAYTPGV
     ARVCQAIAEN PADARRLTIK RNTVAVVSDG SAVLGLGNLG PAASLPVMEG KAALFKRFGG
     VDAWPVVLDT QDTDEIVSIV KAIAPAYGGI NLEDIAAPRC FEIEARLREA LDIPVFHDDQ
     HGTAICVLAA LTNALRVVGK QLADVRVVVS GAGAAGTAIM KLLLRQGVGD IIATDRQGAL
     HRGMTGLNPA WQWLAEHTNK ENYSGDLRGA VRGADVFIGV SAPNLLTGED IATMAKDAIV
     FALANPDPEV DPREARKYAA VVATGRSDQP NQINNVLAFP GVFRGMLDAH AEEFTEEMAI
     AAARAIADVV GEDKINPTVI VPSVFDSRVA PAVAAAVRAA AQHPAPAPAA DPGPADLPEI
     AAEASATP
//