ID A0A1C6S055_9ACTN Unreviewed; 748 AA.
AC A0A1C6S055;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=alpha-galactosidase {ECO:0000256|ARBA:ARBA00012755};
DE EC=3.2.1.22 {ECO:0000256|ARBA:ARBA00012755};
GN ORFNames=GA0070624_2598 {ECO:0000313|EMBL:SCL22742.1};
OS Micromonospora rhizosphaerae.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=568872 {ECO:0000313|EMBL:SCL22742.1, ECO:0000313|Proteomes:UP000199413};
RN [1] {ECO:0000313|Proteomes:UP000199413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45431 {ECO:0000313|Proteomes:UP000199413};
RA Varghese N., Submissions Spin;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC residues in alpha-D-galactosides, including galactose
CC oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001255};
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DR EMBL; FMHV01000002; SCL22742.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6S055; -.
DR STRING; 568872.GA0070624_2598; -.
DR Proteomes; UP000199413; Unassembled WGS sequence.
DR GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR CDD; cd14791; GH36; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.70.98.60; alpha-galactosidase from lactobacil brevis; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR038417; Alpga-gal_N_sf.
DR InterPro; IPR002252; Glyco_hydro_36.
DR InterPro; IPR031705; Glyco_hydro_36_C.
DR InterPro; IPR031704; Glyco_hydro_36_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43053:SF3; ALPHA-GALACTOSIDASE C-RELATED; 1.
DR PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR Pfam; PF16874; Glyco_hydro_36C; 1.
DR Pfam; PF16875; Glyco_hydro_36N; 1.
DR Pfam; PF02065; Melibiase; 1.
DR PRINTS; PR00743; GLHYDRLASE36.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000199413}.
FT DOMAIN 26..294
FT /note="Glycosyl hydrolase family 36 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16875"
FT DOMAIN 653..733
FT /note="Glycosyl hydrolase family 36 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16874"
FT REGION 106..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 81171 MW; 07CDD40CA52C385F CRC64;
MAMTIPTIVH LRRARTSLVL DARGPGLPRV VHWGADLGPL DAADLTDLVD ATIPPVMPSS
FDAPTVLSLL PEPSAGWSGR PGLAGHRDGR DWSTAFRLHA LDVSDGGETA TAAGSPDPSR
VAAGGDAVGV PEEDGEHGGP GAARVTVQAS DPGAELSLTV EIELDPTGLL LLRHRLRNDG
AGAYELRELA PVLPVPAVAT ELLDLTGRWC RERAPQRHPW PMGTWVREGR HGRTGHDATL
LLVAGTAGFG FGHGEVWAVH TAWSGDHVTF AERRPTGEST LGGAELLTPG EIVLAAGEEY
VTPLLYAVWS DAGLDGLSDV LHTHLRARPQ HPRPPRPVTL NVWEAVYFDH ELPRLSALAD
RAAEVGVERF VLDDGWFRGR RHDRAGLGDW WVDDDVWPDG LQPLIDRVCG LGMQFGLWVE
PEMVNPDSDL FRAHPDWVLS VPGRLPPEWR HQQVLDLAHP DAYEHLLSRL DAVLTEHQGI
AYLKWDHNRD LTEAGHQGRP GVHAQTVAVY RLLDELRRRH PEVEIESCSS GGARVDLEIL
RRTDRVWASD CNDALERLAI QRWTGLLLPP ELVGSHIGPE RSHTTHRVHD LGFRAATALF
GHHGIEWDIG AITAAERAEL AAWVALHKRL RPLLHSGRAV RVDHPDPAVW AHGVVAGDGS
QAVYAVARLA TSVAQVPGTV RLPGLDRQRR YAVRLAAGVP GPAVLQLSEP GWLPKGVTLS
GAVLGTVGLQ MPALHPEQTL LLEVTAVD
//
