ID A0A1C6SCU1_9ACTN Unreviewed; 631 AA.
AC A0A1C6SCU1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Cytochrome c-type biogenesis protein CcmF {ECO:0000313|EMBL:SCL27226.1};
GN ORFNames=GA0074692_2313 {ECO:0000313|EMBL:SCL27226.1};
OS Micromonospora pallida.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=145854 {ECO:0000313|EMBL:SCL27226.1, ECO:0000313|Proteomes:UP000198959};
RN [1] {ECO:0000313|EMBL:SCL27226.1, ECO:0000313|Proteomes:UP000198959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43817 {ECO:0000313|EMBL:SCL27226.1,
RC ECO:0000313|Proteomes:UP000198959};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC subunit of a heme lyase. {ECO:0000256|ARBA:ARBA00037230}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC {ECO:0000256|ARBA:ARBA00009186}.
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DR EMBL; FMHW01000002; SCL27226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6SCU1; -.
DR STRING; 145854.GA0074692_2313; -.
DR OrthoDB; 9814290at2; -.
DR Proteomes; UP000198959; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR032523; CcmF_C.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003567; Cyt_c_biogenesis.
DR InterPro; IPR003568; Cyt_c_biogenesis_CcmF.
DR PANTHER; PTHR43653; CYTOCHROME C ASSEMBLY PROTEIN-RELATED; 1.
DR PANTHER; PTHR43653:SF1; CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF; 1.
DR Pfam; PF16327; CcmF_C; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01410; CCBIOGENESIS.
DR PRINTS; PR01411; CCMFBIOGNSIS.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytochrome c-type biogenesis {ECO:0000256|ARBA:ARBA00022748};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..288
FT /note="Cytochrome c assembly protein"
FT /evidence="ECO:0000259|Pfam:PF01578"
FT DOMAIN 329..605
FT /note="Cytochrome c-type biogenesis protein CcmF C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16327"
SQ SEQUENCE 631 AA; 64760 MW; A245073CFF29E928 CRC64;
MLGDFGTASL AAGLVAAPLA ALLWLRVALA GAPARPARLA TVGALLAAGA ACAALEAALL
APDFSVRFVA ENGGRHVPTY YAVTSLWSAM DGSLLLWLLV LAGYGALLAR GRPDRLRGYA
MVVVSVVSTG FFALSTFAAN PFRTVDPVPL DGPGPNPLLQ QHPAMGVHPP LLYAGYLGML
VPFALALAAP LAGRAGRRWL RVARPWALAA WCALTAGIVL GAWWSYAVLG WGGYWAWDPV
ENASLLPWLT TTALLHTSLA GRARERWNQV LACAGFLLVL LGTFLTRSGA VASVHAFTES
PLGPLLLGFV LLAVLAATVL TGRRQQPGSL PNAAPLWSRR TAVLVNAVLL VTVTAVVLIG
TVLPLLTEPL TGSRASVGAS YYQRTAVPLA VVVLLLAGLP PALRGRNPGE ARRRLVLPGA
AALATVATVG LLSRPGPAAL TAFGAAAFVL TGLVATRARP RAAALGHAGL ALLAVGVAAS
SAYARADERT LRVGETLRVS DVSARLTSVQ RAAPGGRMTV RARLAVSSGD TTRTAAPALR
YDPARDTVVT VPAIDEGLRR DVYLTLLAVA EDGGSATVRL AVNPLVGLIW AGGAVGTAGG
LLAVAGVARS RRPRRPEPVA AGAPVAAGAP A
//
