ID A0A1C6SLR1_9ACTN Unreviewed; 1216 AA.
AC A0A1C6SLR1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GA0070616_4079 {ECO:0000313|EMBL:SCL30461.1};
OS Micromonospora nigra.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=145857 {ECO:0000313|EMBL:SCL30461.1, ECO:0000313|Proteomes:UP000199699};
RN [1] {ECO:0000313|EMBL:SCL30461.1, ECO:0000313|Proteomes:UP000199699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43818 {ECO:0000313|EMBL:SCL30461.1,
RC ECO:0000313|Proteomes:UP000199699};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FMHT01000003; SCL30461.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6SLR1; -.
DR STRING; 145857.GA0070616_4079; -.
DR OrthoDB; 163538at2; -.
DR Proteomes; UP000199699; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 2.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 2.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SCL30461.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000199699};
KW Transferase {ECO:0000313|EMBL:SCL30461.1}.
FT DOMAIN 352..568
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 619..734
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 667
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1216 AA; 130359 MW; DBBA4FA178A13E81 CRC64;
MSSAQGGVDG GSPSGTVDAI PPLLVAAFAG GGEMGALIRD HDWAVSPLGT PDRWPAALVS
AVGMMLASKS QIAMFWGEDL RAFYNDAYRP TIGDKHPHVL GQPAREHWAE TWEILGPVLA
GVFRTGESYQ GRDHHFLLDR HGFVEDVYFD VSYDPIREAD GSINGVLCIC SETTGRVLGE
RRLRTLAELG SKLADLDSGA ELGRAAATVL DRHRADVPFG LLYLRDHDGH LRLAGRSGPA
PGVAEPTRAL VEAAATGVAG TISVADLLGH VPPDAADEAV VLPISATNER AGVLVLGVAR
RLPLGDEYRD FLELVAAQIS RAVGQQRAYE QERARAAELA ALDLAKTNFF ANVSHEFRTP
LTLVLGPLED MLADPELPEA YPQQLTMMHR NALRLLKLVN TVLDFSRLES GRLAAHYVPT
DLSNYTARLA STFRSATERA GLRLVVDCPP LPTPVYVDRD MWEKVVLNLV SNAVKFTFDG
SIRVSVRAVD GAARLEVADT GVGILPEEMP HVFERFHRVP GVRARTHEGT GIGLALVREL
VEMHGGRVEV RSRVDEGSTF TVTVPFGSAH LPAERLGDGS PAEDELHQAR LFVAETALWS
AGADAPQPAA RPAAGARGRI LVVDDNGDLR DHVTRLLAPS WEVVTAGDGL EGLRLATHDP
FDLVLTDVMM PRLDGFGLVT ALRADPRTRY VPIVLLSARA GSAEAVAGLA VGADDYLTKP
FSGEELVARV RANVELGQLR GQIIRRLRAL ADAAVAVNTA RSTADVLQVA ARHALSLAEA
DRVVVSATGA RCEADAGDAS SVEPSFVLPL TATAGEQLGE LRVWRPVTDE VGTDEAALAQ
LARLVGVRLE NAQLYEAEHH IATTLQHSLL PRTLPQLPGA VVASRYLPGS ADVEVGGDWY
DVVAVGEDEL VLVIGDVVGK GVRAAAAMGQ LRNGLRAYVL EGFDPGESLT RLNRLVGSTE
VRSFATVFCL WYSPRTGRLR YASAGHPSPL AIRGGDVAFL HDRALGPPVG ALPDTVYPTV
SGELAVGDRL LLYTDGLIED RHLGIDAALA QLRVDATRPG EHVADLIDAV VERVAGQPRR
DDVAVLAMEA AELNRFALCL PAEPTRLSVL RKRLEDFLLA HGVGETDLFD LTVAVSEAAA
NAIEHPVDPA EPTIDVDVRI EDRTVIATVH DSGRWRESTG AGFRGRGLSL IRALGELTVS
RTAEGTDVTL RRRLRD
//
