ID A0A1C6SVF7_9ACTN Unreviewed; 1220 AA.
AC A0A1C6SVF7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GA0074692_3617 {ECO:0000313|EMBL:SCL33624.1};
OS Micromonospora pallida.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=145854 {ECO:0000313|EMBL:SCL33624.1, ECO:0000313|Proteomes:UP000198959};
RN [1] {ECO:0000313|EMBL:SCL33624.1, ECO:0000313|Proteomes:UP000198959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43817 {ECO:0000313|EMBL:SCL33624.1,
RC ECO:0000313|Proteomes:UP000198959};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FMHW01000002; SCL33624.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6SVF7; -.
DR STRING; 145854.GA0074692_3617; -.
DR OrthoDB; 163538at2; -.
DR Proteomes; UP000198959; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 2.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 2.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 2.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS51746; PPM_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SCL33624.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000313|EMBL:SCL33624.1}.
FT DOMAIN 358..574
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 624..739
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 886..1094
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 672
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1220 AA; 130378 MW; 0E001E254C40DED6 CRC64;
MSSAQGGVDE HGPFRGTAVE TVPPPLAAAF AAGGEMGARI RDLDWTDTPL GHPKQWPPAL
ANAIAMMLTS KAQIVMFWGA DHRAFYNDAY LPTIGTKHPH ALGQPAREYW VETWADLGPL
LEGVRGTGEP YRAEDRPFLL HRHGFLEQVY FDVSYDPLRV DDGSISGVYC IVNETTGRVL
GERRLRALAD LGARLADVGS SAELGRATAE VLAAHHVDVP LGLLYLTDDT GRVTLTGCSG
VDPERVVPSD ALPAAVREAL AGADARPVDV TDVVATAPAG TAPRALVLPV LATNEPVGAL
VLGASERLPV TTEYRTFLDL VAAQVSRAVT RQRAHEQEQA RVAELAALDR AKTNFFANVS
HEFRTPLTLV LGPLEDLLAD PDLPVRHTER LTVTHRNALR LLKLVNTVLD FSRLESGRLT
ADYRPTDLAD YTARLASTFR SATERAGLRL TVDCPPLPAP VFVDRDMWEK IVLNLLSNAV
KFTFDGEIQV RLRAVAGAAR LAVTDTGVGI ADDELPHVFE RFHRAAGVRS RTHEGTGIGL
ALVRELVEMH GGAVDVTSRV GAGSTFTVTV PFGSAHLPAD RVSAGPSPLG DFPQALSYVA
EAAFWSAQPP AAGTAGRTGR RGGQILVVDD NADLREHVTR LLAPFWEVVA VPDGVAALDV
LETTSFDLVL ADVMMPRLDG FGLVTALRAN PRTRYVPIVL LSARAGSAEA VAGLSVGADD
YLTKPFSGQE LIARVRANVE LGQLRGQIIR RLRALTDAAV AINTARSTAD VVAVAARHAL
TLVDGARAVV TAAGARHEAD GGGDSSGDPS VVLPLAGTTG EALGELRIWR RTGARDDAEE
AALTELARLI GVRLENARLY EAEHRIATTL QHSLLPRSLP QVPGAVVASR YLPGSADVEV
GGDWYDVIEV DDELVLVIGD VVGKGVHAAA AMGQLRNGLR AYVLEGFDPG ESLTRLNRLV
GSVERRSSAT VVCLCFNPHT GRLRYASAGH PPPLLIGGGD VAFLHDRALG PPVGAIPDTS
YGTEVASLDP GSRLLLYTDG LVEDRHLGID VGLDQLRSDV AGFDGHVADL VDAVVERVVE
RPRRDDVAVL ALEATEQDRF IMRLPADPTR LSVLRKRVED FLVAHDVGET DLFDLTVAVS
EAAANAIEHP VAPAEPVISV EMTIEDRTVV VTVRDSGQWR ESSGSEFRGR GLSLIRALGD
LAVSRTATGT EVTLRRRLTD
//
