ID A0A1C6SXC7_9ACTN Unreviewed; 344 AA.
AC A0A1C6SXC7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:SCL34148.1};
GN ORFNames=GA0074692_3757 {ECO:0000313|EMBL:SCL34148.1};
OS Micromonospora pallida.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=145854 {ECO:0000313|EMBL:SCL34148.1, ECO:0000313|Proteomes:UP000198959};
RN [1] {ECO:0000313|EMBL:SCL34148.1, ECO:0000313|Proteomes:UP000198959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43817 {ECO:0000313|EMBL:SCL34148.1,
RC ECO:0000313|Proteomes:UP000198959};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate
CC + CO2 + NADH; Xref=Rhea:RHEA:32271, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17865, ChEBI:CHEBI:35121, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.1.1.85;
CC Evidence={ECO:0000256|ARBA:ARBA00000624};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; FMHW01000002; SCL34148.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6SXC7; -.
DR STRING; 145854.GA0074692_3757; -.
DR OrthoDB; 5289857at2; -.
DR Proteomes; UP000198959; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR43275; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR PANTHER; PTHR43275:SF1; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW Manganese {ECO:0000256|ARBA:ARBA00023211}.
FT DOMAIN 3..338
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 344 AA; 36043 MW; CEA05DAD42B36551 CRC64;
MARIAVVAGD GIGPEVVTQA LKVVDAVLPG VVETTEYDLG AARYHRTGEV LPDSVLTELA
GHDAILLGAV GDPSVPPGVL ERGLLLKLRF DFDQYVNLRP SRLWAGTTGP LATVKPGEVD
LVVVREGTEG LYAGAGGALH RDTPAEVATE ESLNTRHGVE RVIRDAFARA ARRERRKVTL
VHKTNVLTHA GSLWARAFAA VAAEHPDVTT EYQHVDAAAM FLVTQPQRYD VVVTDNLFGD
ILTDIAAAVT GGIGLAASGS INPDGRYPSM FEPVHGSAPD IAGKGLADPV AAVLSAALLL
EQLGHADAAV RVTEAVATEL ANRTPGEPLR TDEVGDRLAG YAAG
//
