ID   A0A1C6SXI2_9ACTN        Unreviewed;      1073 AA.
AC   A0A1C6SXI2;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Cu/Ag efflux pump CusA {ECO:0000313|EMBL:SCL34059.1};
GN   ORFNames=GA0070624_4892 {ECO:0000313|EMBL:SCL34059.1};
OS   Micromonospora rhizosphaerae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=568872 {ECO:0000313|EMBL:SCL34059.1, ECO:0000313|Proteomes:UP000199413};
RN   [1] {ECO:0000313|Proteomes:UP000199413}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45431 {ECO:0000313|Proteomes:UP000199413};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FMHV01000002; SCL34059.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6SXI2; -.
DR   STRING; 568872.GA0070624_4892; -.
DR   OrthoDB; 3306666at2; -.
DR   Proteomes; UP000199413; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF4; SLR6043 PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199413};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        399..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        486..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        876..893
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        905..923
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        929..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        977..997
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1009..1033
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          372..511
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          1041..1073
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1073 AA;  114519 MW;  0C8D19725279272E CRC64;
     MMRWIVGSSV KYQRLVLAIA VALMAVGFVQ LRNTSVEALP EFGPVRVDVQ VEALGLSAEE
     VENLITNPME NEFFNGIPWL AKLESRTLPG LSSMEMTFEP GTDPIRARQV VQERLTMVAM
     LPAASSRPPL VVQPLSSTSR LMMIGLSSQD RSLIDMSLLS RWTIVPRLLS VPGVANVSIW
     GFRDRQLQVQ VDPAKLMQHG VTLDQVLRTS ANALWVSPLT FVEASTPGLG GFIDTANQRI
     EIQHNQPIKT AADLGKVTVQ GAEDRGVLLG DVTQIVEDHQ LLIGDAVVKD APSLMLVVER
     FPGAKVADVT RDVEAALDEL QPAMPNVQID TTVYRPATFI EKMVDNLTAT LILGAILLLL
     VLGAFLFSWR TALVSLLTIA SSVAVTLLVL SWFGVALNMM SLAGLVMALA IVVDDAVVAV
     DNVRQRLRQR REDGVEEPVP DTIRAAILEA RGPLFVAAVI AAVSVVPLFI LDGVRGAFLT
     PVAQGFLAAT VVSLVVALTV APVLATLLLS RSSLQHGQSP LARALERAYA GLLPRLLRRP
     VWSYALVGLL VVAGLAALPF LGSRPLSPTL QERDLLITWE APPGTSRPEM NRITGALSGE
     LRAVRGVRNV GAHTGRALAS DQVVNMNSGE VWLSIDPAAD YGRTLTAVQR VVDGYPGVQS
     DVITYSDKRV REVVTRGATE DLIVRIYGND YAVLNEKAQE VLGIISAVDG VTEPRVRSAE
     VAPTVEIEVS VAKAAKYGLK PGDVRRAAAT LVSSTVAGNL FDDQKVFEVV VWGVPAVRQN
     MSTIQNLLID APVGGPGGGP TQVRLADVAD VRIVAKPEVI THDQVSRSMD VVANVRGRGL
     GAVTSEVKDR LAQVTFPREH HLEVLGEAQA KASSDFRVWT VVIGAVILIF FLLQAGFASW
     RVASLYFLLL PTALAGGLLL AAIDRSAVSV VALLGLLTVL ALAVRGGMLQ IRRYQRLAEE
     GHPHGAGLVE LGSRQQFIPA VTGMLAAGLA LVPMVIYGSV AGLEIVSPLA LIILGGLVTT
     ALLNLLVLPV LYLRFAVRSR SGPTSEPAAT SLPAPRPRPG TAGKETPSTP APA
//