ID   A0A1C6TA72_9ACTN        Unreviewed;       980 AA.
AC   A0A1C6TA72;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Ribonuclease E {ECO:0000313|EMBL:SCL38710.1};
GN   ORFNames=GA0070624_6309 {ECO:0000313|EMBL:SCL38710.1};
OS   Micromonospora rhizosphaerae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=568872 {ECO:0000313|EMBL:SCL38710.1, ECO:0000313|Proteomes:UP000199413};
RN   [1] {ECO:0000313|Proteomes:UP000199413}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45431 {ECO:0000313|Proteomes:UP000199413};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   EMBL; FMHV01000002; SCL38710.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6TA72; -.
DR   STRING; 568872.GA0070624_6309; -.
DR   OrthoDB; 9804278at2; -.
DR   Proteomes; UP000199413; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd04453; S1_RNase_E; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR   InterPro; IPR004659; RNase_E/G.
DR   InterPro; IPR003029; S1_domain.
DR   NCBIfam; TIGR00757; RNaseEG; 1.
DR   PANTHER; PTHR30001; RIBONUCLEASE; 1.
DR   PANTHER; PTHR30001:SF0; RIBONUCLEASE G; 1.
DR   Pfam; PF10150; RNase_E_G; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50126; S1; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199413};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          475..558
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   REGION          1..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..909
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          921..980
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..278
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..299
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..351
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..421
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        887..909
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   980 AA;  106442 MW;  E40CC30E005768B3 CRC64;
     MLENEPKGGE RTGSQPAGET ADNNTNNTTE AKAPARKRTS RRRAAPLNQP EQTEAPVEAS
     TDAGSTTGEA PQGEVVVPVA GEQEETPKTP RRRRKATTAK AAEEPVIATD AEEASEEVVP
     PVKVTRTRRK KAVPPAAEAA AAETPAAEPA AGPEAGPESV EETEVEPVPA EEIAAEPTPT
     ETGAAEVPPA AETRQAGEVA PGAAVRGGPE EAGEEPEPRT RRRRAALTAP TVLFMAPQPE
     EIPAARVTPP AAEQPPAEEP AETGRRRRRG RREAEPVEVE AEEEPVEVEA EEAAEAEEDE
     ETDTGRRRRR RGRRGRGRGK GGVEDLEEEE AEEATEAESA EAEAEEAEEE AEGEGMTRRR
     RRRRRRGAAD VEATTEDGVP TVVKIREPRR AVDEVQGVSG STRLEAKRQR RRDGREQRRT
     RPPILSESEF LARREAVDRV MAVRQRGDRT QIGVLEDGVL VEHYVTRNST ATMAGNVYLG
     KVQNVLPSME AAFVDIGRGR NAVLYAGEVN WDATGLEGRA RSIEQALKSG DSVLVQVTKD
     PIGHKGARLT SHIALSGRHL VYVPHGNASG ISRKLPDTER KRLRDILKKL VPDGAGVIVR
     TAAEGASEDE LARDVKRLQA QWEEIQAKAA EGGAPVLLYE EPDLVIRVVR DLFNEDFRDL
     VIEGDQAYDM VESYLSQVSP DLVSRLRRHV GTTDVFAEYR IDEQILKGLD RKVFLPSGGS
     LVIDRTEAMT VIDVNTGKYT GSGGNLEETV TRNNLEAAEE IVRQLRLRDL GGIVVIDFID
     MVLESNRELV LRRLTECLGR DRTKHQVTEI TSLGLVQMTR KRIGAGLLEA FSETCECCKG
     RGLIIHTEPV PEKPRGGGAG EKVKAVASAV TTPPAEQAAG GTARRRARKS AAQEKTVAEV
     TEDRADADYH DTMGYDLSRY ETETPAAPAV ADSQEGESAR LAAPDDPDAL GEGETETEGT
     EGGTSRRRSR RGGARRRTRP
//