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Database: UniProt
Entry: A0A1C6TB74_9ACTN
LinkDB: A0A1C6TB74_9ACTN
Original site: A0A1C6TB74_9ACTN 
ID   A0A1C6TB74_9ACTN        Unreviewed;       318 AA.
AC   A0A1C6TB74;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   13-FEB-2019, entry version 12.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=GA0074692_5216 {ECO:0000313|EMBL:SCL39024.1};
OS   Micromonospora pallida.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Micromonospora.
OX   NCBI_TaxID=145854 {ECO:0000313|EMBL:SCL39024.1, ECO:0000313|Proteomes:UP000198959};
RN   [1] {ECO:0000313|EMBL:SCL39024.1, ECO:0000313|Proteomes:UP000198959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43817 {ECO:0000313|EMBL:SCL39024.1,
RC   ECO:0000313|Proteomes:UP000198959};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; FMHW01000002; SCL39024.1; -; Genomic_DNA.
DR   BioCyc; GCF_900090325:GA0074692_RS25575-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000198959; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198959};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN        8    186       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      201    278       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        179    179       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   318 AA;  33172 MW;  8227C0F1D917ABCD CRC64;
     MPGTPPTRFV YLGPEGTFAE QALRTVPAAE RGTRTPARSV GEALDNVRAG EADAALVPLE
     NSIGGAVGVT LDEMAEGDPL VITREVVLPV EFVLGARPGT ALHDIRSVAA HPQASTQCRN
     WLRGHLPDAT VVDVLSNGAA AGGAASGEYD AAICAPIGAA RHRLAVLANK IADHPDAVTR
     FALVSRPGPP PPPTGDDLTS LAVYIAHDRV GALLSVLMEL AVRGVNLTRI ESRPTGEALG
     RYVFFLDCAG HVADVRLGEA LQGLRRVCAD VRFLGSYPRH RFGDGSGDRP VPAPAGLSDA
     DYADAAAWLS RIRAGTLP
//
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