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Database: UniProt
Entry: A0A1C6TW68_9ACTN
LinkDB: A0A1C6TW68_9ACTN
Original site: A0A1C6TW68_9ACTN 
ID   A0A1C6TW68_9ACTN        Unreviewed;       924 AA.
AC   A0A1C6TW68;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN   ORFNames=GA0070617_0093 {ECO:0000313|EMBL:SCL45938.1};
OS   Micromonospora yangpuensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=683228 {ECO:0000313|EMBL:SCL45938.1, ECO:0000313|Proteomes:UP000198937};
RN   [1] {ECO:0000313|EMBL:SCL45938.1, ECO:0000313|Proteomes:UP000198937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45577 {ECO:0000313|EMBL:SCL45938.1,
RC   ECO:0000313|Proteomes:UP000198937};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in initiation and elongation during chromosome
CC       replication; it exhibits DNA-dependent ATPase activity.
CC       {ECO:0000256|ARBA:ARBA00002835, ECO:0000256|RuleBase:RU362085}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665,
CC         ECO:0000256|RuleBase:RU362085};
CC   -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC       {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
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DR   EMBL; FMIA01000002; SCL45938.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6TW68; -.
DR   STRING; 683228.GA0070617_0093; -.
DR   OrthoDB; 9773982at2; -.
DR   Proteomes; UP000198937; Unassembled WGS sequence.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR   CDD; cd00984; DnaB_C; 1.
DR   Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR   InterPro; IPR007692; DNA_helicase_DnaB.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR   InterPro; IPR016136; DNA_helicase_N/primase_C.
DR   InterPro; IPR003587; Hint_dom_N.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR030934; Intein_C.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00665; DnaB; 1.
DR   NCBIfam; TIGR01443; intein_Cterm; 1.
DR   PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR   PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR   Pfam; PF00772; DnaB; 1.
DR   Pfam; PF03796; DnaB_C; 2.
DR   Pfam; PF14528; LAGLIDADG_3; 1.
DR   SMART; SM00306; HintN; 1.
DR   SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR   SUPFAM; SSF55608; Homing endonucleases; 1.
DR   SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU362085};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU362085};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362085}; Primosome {ECO:0000256|RuleBase:RU362085};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198937};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          204..241
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   DOMAIN          468..606
FT                   /note="DOD-type homing endonuclease"
FT                   /evidence="ECO:0000259|PROSITE:PS50819"
FT   DOMAIN          698..924
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   924 AA;  100866 MW;  D2A84491356A7CB5 CRC64;
     MSVTDDRRTE PRVGGQGPAP APRDGQFEKT PPQDIAAEQC VLGGMLLSKD AVADVVEILK
     PNDFYRPVHT TIFDAILDIY GRGEPADAIT VAAALADSGD LGRIGGAPYL HTCMAAVPTA
     ANAGYYARIV SERAVLRRLV EAGTRIVQLG YGTAAGGSRD VDDVVDLAQQ AVYDVTERRV
     SEDFAILADM LQPTLDEIEA VGAQGGMMTG VPTGFSDLDR LLNGLHAGQL IIVAGRPGLG
     KALALDTPLP TPEGWTTMGE VGVGDRLLGA DGKPTTITNA FDVMYGRPCY EVEFSDGSVI
     VADAEHLWKT TTRASRRQRT EMRPSHQWRE DARLAAAAAH RVAMAAPDRL ITFAEPVESA
     GEQFRNVLHV VGSQVGTAGA VQREYVRRGQ PWRRTICAYS AHALFGVLSD RVNRKMNAEV
     TVSHDWAVTT EHIAATLRHP TDGRANHAVE NAQPLALPAQ DLPVAPYTLG AWLGDGNSAD
     SRITTADPEI LRLVEQEGFD TTQSTASPLL YTIRPRRGCG CVGRADCPIC HGQPSSLMKA
     LRAVGVLNNK HIPQQYLRAS ERQRRTLLAG LLDTDGTVTL RGNVQFTTTS SRLAEGVYEL
     VVSLGYRCSV ARKLVSGRTP ESSVAYNLNF TTTDEVFRLS RKREAHRGRR CSDSNSRTGS
     RYIVDVRPVP SVPVRCVTVD NSDHLYLAGR SMIPTHNSTA SMDFARNAAI RANQAAAIFS
     LEMSKVEIVM RLLSAEARVP LHVLRSGQLS DDDWTKLARC MGEISEAPLF VDDTPSMNLM
     EIRAKARRLK QRHDLKMIVV DYLQLMTSPK RTESRQQEVA DLSRGLKLLA KEVECPVIAV
     SQLNRGPEQR TDKRPQLSDL RESGSIEQDA DVVILLHRDD YYDKESPRAG EADFIIAKHR
     NGPTDTVTVA AQLHLSRFVD MAIV
//
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