ID A0A1C6TW68_9ACTN Unreviewed; 924 AA.
AC A0A1C6TW68;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN ORFNames=GA0070617_0093 {ECO:0000313|EMBL:SCL45938.1};
OS Micromonospora yangpuensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=683228 {ECO:0000313|EMBL:SCL45938.1, ECO:0000313|Proteomes:UP000198937};
RN [1] {ECO:0000313|EMBL:SCL45938.1, ECO:0000313|Proteomes:UP000198937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45577 {ECO:0000313|EMBL:SCL45938.1,
RC ECO:0000313|Proteomes:UP000198937};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity.
CC {ECO:0000256|ARBA:ARBA00002835, ECO:0000256|RuleBase:RU362085}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU362085};
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
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DR EMBL; FMIA01000002; SCL45938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6TW68; -.
DR STRING; 683228.GA0070617_0093; -.
DR OrthoDB; 9773982at2; -.
DR Proteomes; UP000198937; Unassembled WGS sequence.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR CDD; cd00984; DnaB_C; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007692; DNA_helicase_DnaB.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00665; DnaB; 1.
DR NCBIfam; TIGR01443; intein_Cterm; 1.
DR PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF03796; DnaB_C; 2.
DR Pfam; PF14528; LAGLIDADG_3; 1.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS51199; SF4_HELICASE; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU362085};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU362085};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362085}; Primosome {ECO:0000256|RuleBase:RU362085};
KW Reference proteome {ECO:0000313|Proteomes:UP000198937};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 204..241
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT DOMAIN 468..606
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 698..924
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 924 AA; 100866 MW; D2A84491356A7CB5 CRC64;
MSVTDDRRTE PRVGGQGPAP APRDGQFEKT PPQDIAAEQC VLGGMLLSKD AVADVVEILK
PNDFYRPVHT TIFDAILDIY GRGEPADAIT VAAALADSGD LGRIGGAPYL HTCMAAVPTA
ANAGYYARIV SERAVLRRLV EAGTRIVQLG YGTAAGGSRD VDDVVDLAQQ AVYDVTERRV
SEDFAILADM LQPTLDEIEA VGAQGGMMTG VPTGFSDLDR LLNGLHAGQL IIVAGRPGLG
KALALDTPLP TPEGWTTMGE VGVGDRLLGA DGKPTTITNA FDVMYGRPCY EVEFSDGSVI
VADAEHLWKT TTRASRRQRT EMRPSHQWRE DARLAAAAAH RVAMAAPDRL ITFAEPVESA
GEQFRNVLHV VGSQVGTAGA VQREYVRRGQ PWRRTICAYS AHALFGVLSD RVNRKMNAEV
TVSHDWAVTT EHIAATLRHP TDGRANHAVE NAQPLALPAQ DLPVAPYTLG AWLGDGNSAD
SRITTADPEI LRLVEQEGFD TTQSTASPLL YTIRPRRGCG CVGRADCPIC HGQPSSLMKA
LRAVGVLNNK HIPQQYLRAS ERQRRTLLAG LLDTDGTVTL RGNVQFTTTS SRLAEGVYEL
VVSLGYRCSV ARKLVSGRTP ESSVAYNLNF TTTDEVFRLS RKREAHRGRR CSDSNSRTGS
RYIVDVRPVP SVPVRCVTVD NSDHLYLAGR SMIPTHNSTA SMDFARNAAI RANQAAAIFS
LEMSKVEIVM RLLSAEARVP LHVLRSGQLS DDDWTKLARC MGEISEAPLF VDDTPSMNLM
EIRAKARRLK QRHDLKMIVV DYLQLMTSPK RTESRQQEVA DLSRGLKLLA KEVECPVIAV
SQLNRGPEQR TDKRPQLSDL RESGSIEQDA DVVILLHRDD YYDKESPRAG EADFIIAKHR
NGPTDTVTVA AQLHLSRFVD MAIV
//