ID A0A1C6UGJ2_9ACTN Unreviewed; 1829 AA.
AC A0A1C6UGJ2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SCL53092.1};
GN ORFNames=GA0070603_1530 {ECO:0000313|EMBL:SCL53092.1};
OS Micromonospora chersina.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=47854 {ECO:0000313|EMBL:SCL53092.1, ECO:0000313|Proteomes:UP000198605};
RN [1] {ECO:0000313|EMBL:SCL53092.1, ECO:0000313|Proteomes:UP000198605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44151 {ECO:0000313|EMBL:SCL53092.1,
RC ECO:0000313|Proteomes:UP000198605};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FMIB01000002; SCL53092.1; -; Genomic_DNA.
DR STRING; 47854.GA0070603_1530; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000198605; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1421..1442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1449..1470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1476..1496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1508..1537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1543..1564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1594..1620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1626..1648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1655..1674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1680..1702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1722..1742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1770..1792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1001..1078
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1829 AA; 196987 MW; 0992D00203F46329 CRC64;
MTDLKDPARE AARQALIAKR LRARQAAPAA RITPRPAGAE VPLSYAQERV WFMDQLAPGE
AAYHIAVPLR VRGPLDVEAL RAALAALSAR HESQRTRFPA DSDGRPTVVV EESVEVPLTI
VDAPDEASAQ ALVDAAAAEP FDLADGPLLR ALLIRLADDD HVLFLGQHHI VGDGWSVDVL
LRDLITLYRG GEPPALPIQY GDFAVWEAEE LDGPQARAHV DYWKQRLAGI TPLELPLDRP
RPATQTYRGD FVEFQLDPAE TEALNALTRA TGGTLFMTLL AAYQVLLARH AGQEDFAVGA
SVAGRSAPEL ENVVGMFINM LPLRAELGGD PTFVELLERT RRSVLDGFEH AEVPFAKVVH
ELGLPRDVSR SPVFQTMFVL QNYEMGRFRG VSRSDEVSFE WTPMELRATR FDFELHAVET
VDGLWGKLVF NTDLFTRDTV ERMARRWTIL LAAVVAAPDT PVSRLELLPA DERALLGLWN
DTAADFPRDQ TLHGPVEDRA AATPDAVAVT IEGRSLTYAE LNVAANRIAH RLRAAGVGPE
TLVGVCAERS VELVAGLLGV LKAGGAYLPL DPEYPADRLA FMVTDADAPV VLVQEHLRDV
LPATAATVLA LDDATVWADQ PATDPAPTAG PEHLAYVIYT SGSTGRPKGV PNTHRGIVNR
LDWMQKTYGL GADDAVLQKT PASFDVSVWE FFWPLRTGAR LVLAKPGGHK DAGYLRDLLV
AERITTAHFV PSMLTVFLAE EGVEAATALR RVICSGEELP LASAVDFTAR LPWCGLHNLY
GPTEAAIDVT AWHCDPARLA EVTGVPIGAP IANLRLHVLD PAGAECPVGV AGELHIGGVG
LARGYHRRPA LTAEKFVPDA FSGEPGARLY RTGDLARWVV APDGTGVIEF LGRIDHQVKL
RGLRIELGEI ESALREQPGV TETAVIVRED SPGDKRLTAY LVGPAEHAAL KAALKETLPE
YMVPAAFVTL DALPLTPNGK LDRRALPAPV VTREASVALV EPRDDTERAL AAIWSEVLGV
DTLGIDDDFF DLGGHSMLAT QVVAKIRKAE LGGRAVGVMD LFQQRTIREL GAYISGDAAE
AGPRRLLYEL TKPISAAQRV LSYVCVPYGG GSAIVYQPLA DALPAGHTLW SLAIPGHDVG
LSEDALPFDE LTTRVADEIL ERVEGPLALY GHCGVGSAIV AEVARKVEAA GRDLDAVYIG
AMFPFARPKG FFAAARNRLE QLRSNKHYAS WLKSMGVDTD ELDPEQADRI ISNMRADSRA
SEEYFTRLLD QRATKLRAPI ISVVGSEDPV TDYYRERYAE WQFLSDTLGL VVLDQAGHFF
LKYRAEELAE IVTRVHPAVV AGDVADLGPQ ARGEDAGWAV LDRLAVGAAE RPAAKTVKPS
MGRFLAITVG QLVSSTGSAL TAFALPIWLF NRTGSVADLG LLWALALICG VFMLPVAGAI
VDRVSRRRIM MLASSAAGSV QLVLAALLWT DNLVLWHIYL LVALSSVAGS FQRIAFQSAV
PQLVPKRYLG HAMGITQLST GVATLLMPVF AAGLLAAIEL KGILLIDVAS YVVAVLTLAV
VRFPDLLGWR PRERLLVAIA NGLRYSWQHR GFRLMLGYFA LGNIFLAPAL VLATPLVLSF
GSPTQVAQVA LAEAVGAVAG GVLMSLWGGP RKRRMIGVLI GNLGTAIGCV LIGLDASVAM
ICVGMAWLAM AMTTAQSIYA TIVQVKVPQR FHGRVFSLNQ TIAWSTLPIG FALLAPGATA
LFEPMLAPGG ALAGSVGAVI GTGPGRGIGF AYVCFGLVLI LITLGGFAIR LLRRFDLEVE
DSLPDDLIGA QERERRLAAR AAEREKVAA
//
