ID   A0A1C6V8Y4_9ACTN        Unreviewed;       790 AA.
AC   A0A1C6V8Y4;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Alpha,alpha-trehalose phosphorylase {ECO:0000313|EMBL:SCL62813.1};
GN   ORFNames=GA0070603_3473 {ECO:0000313|EMBL:SCL62813.1};
OS   Micromonospora chersina.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=47854 {ECO:0000313|EMBL:SCL62813.1, ECO:0000313|Proteomes:UP000198605};
RN   [1] {ECO:0000313|EMBL:SCL62813.1, ECO:0000313|Proteomes:UP000198605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44151 {ECO:0000313|EMBL:SCL62813.1,
RC   ECO:0000313|Proteomes:UP000198605};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC       {ECO:0000256|ARBA:ARBA00006768}.
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DR   EMBL; FMIB01000002; SCL62813.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6V8Y4; -.
DR   STRING; 47854.GA0070603_3473; -.
DR   OrthoDB; 9816160at2; -.
DR   Proteomes; UP000198605; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR   Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR005194; Glyco_hydro_65_C.
DR   InterPro; IPR005195; Glyco_hydro_65_M.
DR   InterPro; IPR005196; Glyco_hydro_65_N.
DR   InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR   InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR   PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR   PANTHER; PTHR11051:SF13; GLYCOSYL TRANSFERASE-RELATED; 1.
DR   Pfam; PF03633; Glyco_hydro_65C; 1.
DR   Pfam; PF03632; Glyco_hydro_65m; 1.
DR   Pfam; PF03636; Glyco_hydro_65N; 1.
DR   PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295}.
FT   DOMAIN          16..270
FT                   /note="Glycoside hydrolase family 65 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03636"
FT   DOMAIN          327..679
FT                   /note="Glycoside hydrolase family 65 central catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF03632"
FT   DOMAIN          689..751
FT                   /note="Glycoside hydrolase family 65 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03633"
FT   REGION          759..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        761..780
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        488
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT   BINDING         361..362
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT   BINDING         592..593
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ   SEQUENCE   790 AA;  88547 MW;  906F7F328B07ED73 CRC64;
     MIRERAYPVE PWHVRETRLD MDVLAQSESV FALSNGHVGL RGNLDEGEPH GLPGTYLNSF
     YELRPLPYAE AGFGFPESGQ TVVNVTNGKL IRLLVDDEPL DVRYGELLSH ERVLDLRAGT
     LHRELHWRSP AGRDVKVRST RLVSFTQRAV AAIHYEVEAL EGPLRLILQS ELVANETLPP
     QSRDPRVAAV LESPLQAEEE LTTDDGGLLI HRTKVSGLRV AAQMAHDVDA PERTSIESEG
     YEDWVRTTIG CVLKPGQTLR VVKYLTYGWS SRRSLPALRD QVGAALAAAR LDGWDGLRRE
     QREYLDEFWD AADVRVEGDP EVQQAVRFGL FHVLQAGARA ERRPIAAKGL TGPGYDGHAF
     WDTEMFVLPV LTYTQPGAVR DALHWRHSTL PQAQERARTL NLAGAAFPWR TIEGPESSAY
     WPAGTAAFHI AADIADALRR YVLVTGDQAL EEEIGLELLV ETARLWRSLG HHDRTGRFHI
     DGVTGPDEYT AVKNDNVYTN LMAQRNLLTA ADCAMRHRDQ ALDLGVTEEE AAAWRDAAAA
     MHLPYDPEIQ VHGQVEGFTR LQEWDFEHTP PEKYPLLLHY PYFDLYRKQV VKQADLVLAM
     HWRGDAFTGP EKMRNFNYYE RRTVRDSSLS ACTQAVMAAE VGHPELAHRY LREAALMDLH
     DLNENTRDGV HMASLAGAWI ALVAGFGGLR DHDGTLSFSP RLPSRLSRLE FSLQWRGMRL
     RVDVRPHQTT YSLRNGGPDT VVELRHHAEP IRITAAQPVT VPVPPAHPSG PQPEQPPGRA
     PLLHLPENMS
//