ID A0A1C6V974_9ACTN Unreviewed; 1163 AA.
AC A0A1C6V974;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GA0070617_5002 {ECO:0000313|EMBL:SCL62707.1};
OS Micromonospora yangpuensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=683228 {ECO:0000313|EMBL:SCL62707.1, ECO:0000313|Proteomes:UP000198937};
RN [1] {ECO:0000313|EMBL:SCL62707.1, ECO:0000313|Proteomes:UP000198937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45577 {ECO:0000313|EMBL:SCL62707.1,
RC ECO:0000313|Proteomes:UP000198937};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FMIA01000002; SCL62707.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6V974; -.
DR STRING; 683228.GA0070617_5002; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000198937; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198937}.
FT DOMAIN 36..365
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 366..698
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 57..64
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1163 AA; 124499 MW; 465989837A67E2AD CRC64;
MTQPALFPAA PAPAPRSADA GPRYTPVELA KLLRLPAPTR EQAAIIAAPV QPLLVVAGAG
SGKTETMAAR VVWLVANSYV RPEHVLGLTF TRKAAGELGH RVRTRLDQLV RRLGRRSRDP
LDDPFAGEPT VSTYHSYAAR IVTEHGLRAG YEPATRLLTE ASRWQLVDLL VRNYDGDMSE
VERMPSTITD AVLALAGELD EHLVDPDTLA AWTGRFFAEV QSRPGRIYAD VRRALARQQT
RLRLLPLVRA YARRKDDFEA MDFADQLARA ARVARDHPGV GEIERDRFRV VLLDEYQDTS
HAQVVLLHSL FGGGHPVTAV GDPCQSIYGW RGASAGTLDR FPGDFVDSVG VPARVLGLTT
SWRNRPEILS VANALATPLR AAGARVPELR AAMSVAEPVA HRSPRGAAGG TLHCALLPTY
VDEAAWIADS VLAAWRGAAR QPDASPEHIP VERRPTTAVL VRLRSQIPAI EAALRDRGLP
VEVVGLGGLL DTPEVRDVVC TLRVLADPTD GAALLRLLTG ARWRIGPRDL VALHRRARTL
ATARQQLTGA DDPEITVDRL DEATLVEALA DLGPAQAYSA EGFARLRAYS RELALLRYRM
DQSLPELIAD VERTIGLDVE VAVRAGRDGT GDAGLARGHL DALGDTAARF SGETPGATLA
GFLAFLTAAE DSERGLTPGE VEVVEGAVQI LTAHAAKGLE WDVVAVAGLT RGGWPGVVRN
SDHWLGGLGV LPFPLRGDAD GLPEFSLDDA EDQRGVARAF ADFTDAWRAH DEREERRLAY
VAVTRPRRLL LCSGYWWGEQ TKRPRGPSVF LREVHDACLA GGAGFLVDEW APEPAGDAVN
PTTEVVLRAE WPADPLGGRR PALTEAAALV RRFLTDPAGP PGDPVGAGGP PDGDAAPGGA
APGGAAPGDA APGDAAPGGD APAGGDDPEV ARWRWEADLL LAERAELLRR AAAVEVVLPE
QLSVTQLVAL RRDPEALART LRRPMPSAPN PYARRGTAFH TWLEQRFGAD RLLDLDELPG
AADAEAAPDE ALVELQERFL ASEWADRVPI EVEVPFATVV AGVVVRGRMD AVFARPGGRF
DVVDWKTGRQ PTGDDAQAAA VQLAVYRLAW AELAGVPVEQ VGAAFHHVRD GVTVRPADLL
DAAGLTALIT ALPEISAGGL HVG
//
