ID   A0A1C6VUD8_9ACTN        Unreviewed;      1002 AA.
AC   A0A1C6VUD8;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Ribonuclease E {ECO:0000313|EMBL:SCL69915.1};
GN   ORFNames=GA0070603_5318 {ECO:0000313|EMBL:SCL69915.1};
OS   Micromonospora chersina.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=47854 {ECO:0000313|EMBL:SCL69915.1, ECO:0000313|Proteomes:UP000198605};
RN   [1] {ECO:0000313|EMBL:SCL69915.1, ECO:0000313|Proteomes:UP000198605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44151 {ECO:0000313|EMBL:SCL69915.1,
RC   ECO:0000313|Proteomes:UP000198605};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   EMBL; FMIB01000002; SCL69915.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C6VUD8; -.
DR   STRING; 47854.GA0070603_5318; -.
DR   OrthoDB; 9804278at2; -.
DR   Proteomes; UP000198605; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd04453; S1_RNase_E; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR   InterPro; IPR004659; RNase_E/G.
DR   InterPro; IPR003029; S1_domain.
DR   NCBIfam; TIGR00757; RNaseEG; 1.
DR   PANTHER; PTHR30001; RIBONUCLEASE; 1.
DR   PANTHER; PTHR30001:SF0; RIBONUCLEASE G; 1.
DR   Pfam; PF10150; RNase_E_G; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50126; S1; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          490..573
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   REGION          1..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          864..1002
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..195
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..290
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..313
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..436
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        889..905
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1002 AA;  108185 MW;  52C5FEAB4676A93C CRC64;
     MLENEPEGGE RTGAEPAEAT ASSSTEGTAE VKPPARKRAS RRKAAPLNQP EQTDAPVEAP
     TAATGSGESP QAEVFAPVAG DLEAAPKTRR RRKATPAKAV EEPVAAAGVE AASDEVVPPV
     KVTRTRRRKT TPPPVEAPAD ESPTEAPAEA AGPAAEPHAV AEPQADVEPA AAPAPAAGEP
     EDEDAVGEDA EDEPTPEDQA RLARAGGPED RTGEVSPGAA VPGPAEEPAP TTRRRRAALS
     APTVLFMPPQ PEEAPVVRVT YPVAEEPVEE PAETGRRRRR GRREAEPVAV EVEVEAEEEP
     TAEAEETAEA EEDEDEAALR RRRRRGRRGR GRGRGAEEAE DEEAEEAVRA EAAEAEAEET
     EDEEEAEGEG MTRRRRRRRR RGAGEAETAA EDGVPTVVKI REPRKAVDEV QGVSGSTRLE
     AKRQRRRDGR EQRRTRPPIL SESEFLARRE AVDRVMAVRQ RGDRTQIAVL EDGVLVEHYV
     TRNSSGTMAG NVYLGKVQNV LPSMEAAFVD IGRGRNAVLY AGEVNWDTTG LEGRARSIEQ
     ALRSGDSVLV QVTKDPIGHK GARLTSHIAL SGRHLVYVPN GNASGISRKL PDTERKRLRD
     ILKKLVPDGA GVIVRTAAEG ASEDELARDV KRLQAQWEEI QAKAAEGGAP VLLYEEPDLV
     IRVVRDLFNE DFRELVIEGE SAYDLVESYL SHVSPDLVAR LRRHAGTTDV FAEYRIDEQI
     LKGLDRKVFL PSGGSLVIDR TEAMTVIDVN TGKYTGSGGN LEETVTRNNL EAAEEIVRQL
     RLRDLGGIVV IDFIDMVLES NRELVLRRLT ECLGRDRTKH QVTEITSLGL VQMTRKRIGA
     GLLEAFSETC ECCKGRGVII HTEPVPEKPR GGAGEKVKAV ASAVTAPAGE EKGRRRGRKA
     APEKPAAEAA EQPAPAAPEK AVAEVVESPD DDYYDTQGYD LSRFESQGVA GPAVTDSQEG
     DSARLAAADD PDALGDGDEE GADTGTARRR SRRGGARRRT RP
//