ID A0A1C6VYR6_9ACTN Unreviewed; 546 AA.
AC A0A1C6VYR6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|RuleBase:RU000612};
DE EC=5.3.1.9 {ECO:0000256|RuleBase:RU000612};
GN ORFNames=GA0070603_5924 {ECO:0000313|EMBL:SCL71426.1};
OS Micromonospora chersina.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=47854 {ECO:0000313|EMBL:SCL71426.1, ECO:0000313|Proteomes:UP000198605};
RN [1] {ECO:0000313|EMBL:SCL71426.1, ECO:0000313|Proteomes:UP000198605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44151 {ECO:0000313|EMBL:SCL71426.1,
RC ECO:0000313|Proteomes:UP000198605};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|RuleBase:RU000612}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|RuleBase:RU000612}.
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DR EMBL; FMIB01000002; SCL71426.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C6VYR6; -.
DR STRING; 47854.GA0070603_5924; -.
DR OrthoDB; 140919at2; -.
DR UniPathway; UPA00109; UER00181.
DR Proteomes; UP000198605; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW ECO:0000256|RuleBase:RU000612};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612}.
FT DOMAIN 83..248
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 546 AA; 55268 MW; A072F5941C858FFF CRC64;
MSDLLAGRAD IAAGLAVHGA DAVDGSAPAS VRAALVAADL PARLAAKDPT LWGPDAEATA
RTRLGWLDTH TRSRELLPQL AELTEELADL DHVVLAGMGG SSLAPEVLAR TLGRPLTVLD
TTDPGQVRAA LADRLERTVV VVASKSGGTV ETDSVRRAYL QAFLDAGLTE AEAARHFVVV
TDPGSPLESV ADEMGVVVIQ SDPEVGGRYS ALTAFGLTPA ALAGVPVADL LDDAEALAGA
LGRDRDNPGL ALGAALGAAA TSGRATVALV SDGTGLDGLG DWVEQLLAES TGKAGRGILP
VVVESPDAPG ATGPGVLTVG YGGALGPGVA PGPADVAVNG PLGAQFLTWE YATAVAAAVL
DVDPFDQPDV AGSKEHTARL LAAGPPAESP SATDGAVEVY APAGAPADLA GALRWLLDGL
GDDGYLAVSA YLDRWADAAV AGLRPLLARA TPRPVTFGWG PRYLHSTGQY HKGGPRAGSH
LQVTGAVTDD LPVPGRPYTF GDLQAAQAAG DRRALADRGR PVLRLHLTER AAGVAQLLDA
AGRTLT
//
