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Database: UniProt
Entry: A0A1C7CZS3_9DIPT
LinkDB: A0A1C7CZS3_9DIPT
Original site: A0A1C7CZS3_9DIPT 
ID   A0A1C7CZS3_9DIPT        Unreviewed;       432 AA.
AC   A0A1C7CZS3;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 2.
DT   31-JUL-2019, entry version 17.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:ACOM042641-PA};
OS   Anopheles coluzzii.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=1518534 {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM042641-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM042641-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mali-NIH {ECO:0000313|Proteomes:UP000075882,
RC   ECO:0000313|VectorBase:ACOM042641-PA};
RX   PubMed=20966253; DOI=10.1126/science.1195755;
RA   Lawniczak M.K., Emrich S.J., Holloway A.K., Regier A.P., Olson M.,
RA   White B., Redmond S., Fulton L., Appelbaum E., Godfrey J., Farmer C.,
RA   Chinwalla A., Yang S.P., Minx P., Nelson J., Kyung K., Walenz B.P.,
RA   Garcia-Hernandez E., Aguiar M., Viswanathan L.D., Rogers Y.H.,
RA   Strausberg R.L., Saski C.A., Lawson D., Collins F.H., Kafatos F.C.,
RA   Christophides G.K., Clifton S.W., Kirkness E.F., Besansky N.J.;
RT   "Widespread divergence between incipient Anopheles gambiae species
RT   revealed by whole genome sequences.";
RL   Science 330:512-514(2010).
RN   [2] {ECO:0000313|VectorBase:ACOM042641-PA}
RP   IDENTIFICATION.
RC   STRAIN=Mali-NIH {ECO:0000313|VectorBase:ACOM042641-PA};
RG   VectorBase;
RL   Submitted (SEP-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   VectorBase; ACOM042641-RA; ACOM042641-PA; ACOM042641.
DR   Proteomes; UP000075882; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000075882};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075882};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   DOMAIN       87    232       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      239    410       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     22       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   432 AA;  49826 MW;  BB500EA22B254CAC CRC64;
     MSFGQRKNFT VPVDAESPEA RDDAKLLPLG PFDKIPPIII DGQDPPKTPI TPTTPIIYCP
     QSPSATSKRS RALRPGTTRK YRRRAILKNG DCNIVLSKVS RQRLRFLQDI FTTLVDAQWR
     WTLLVFAFSF IGSWLFFGAI WWLIAFTHGD LEEMHLPKNQ EESGWKPCVF NIESYTSAFL
     FSIETQTTIG YGYRTTTEEC PEAIFIMCFQ SIYGVMMQAF MVGFVFAKMT RPKHRTQTLL
     FSKHAVVCQR DGELSLMFRV GDMRKSHIIG ANIRAQLIRT KLSREGEVMA QYQHELEVGA
     DHCGSDLFFI WPQIVTHRIN TESPFYNMSA SDLLQDRFEI VVILEGTVES TGQSTQARSS
     YVNTEILWGH RFEPIVFYNK ENQVYEINYS KFNETHSVDT PLCSARELAE FYKYQDDYRN
     QAEDHHHLQT PA
//
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