ID A0A1C7I717_9FIRM Unreviewed; 452 AA.
AC A0A1C7I717;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=A4V09_02895 {ECO:0000313|EMBL:ANU74798.1};
OS Blautia pseudococcoides.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX NCBI_TaxID=1796616 {ECO:0000313|EMBL:ANU74798.1, ECO:0000313|Proteomes:UP000092574};
RN [1] {ECO:0000313|Proteomes:UP000092574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YL58 {ECO:0000313|Proteomes:UP000092574};
RA Uchimura Y., Wyss M., Brugiroux S., Limenitakis J.P., Stecher B.,
RA McCoy K.D., Macpherson A.J.;
RT "Complete Genome Sequences of Twelve Strains of a Stable Defined Moderately
RT Diverse Mouse Microbiota 2 (sDMDMm2).";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
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DR EMBL; CP015405; ANU74798.1; -; Genomic_DNA.
DR RefSeq; WP_065541022.1; NZ_CP065312.1.
DR AlphaFoldDB; A0A1C7I717; -.
DR STRING; 1796616.A4V09_02895; -.
DR KEGG; byl:A4V09_02895; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000092574; Chromosome.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06113; citrate_synt_like_1_2; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000092574};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 330
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 389
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 452 AA; 51648 MW; 298004791C3E1F8A CRC64;
MGFNMKVTPE IEALTKICED HSKMDVSLYA KYDVKRGLRD INGKGVLAGL TQISNIVSYK
EEDGKSVPCD GELYYRGINV EELTKGFLQE KRFGFEEATY LLLFGTLPSQ QQLDDFCKIL
GDQRCLPRNF VRDVIMKAPS RDMMNTLSRS VLTLYSYDTN PEDISLPNVL RQCINLISIF
PMLSVYGYQA HRHYNQNKSL YIHHPKKELS TAENILLMLR PDKKYTPFEA AILDLALVLH
MEHGGGNNST FTTHVVSSSG TDTYSAIAAA LGSLKGPKHG GANIKVVRMF DDMKKHVKDW
KDEGEVSDYL RKLLHKEAFD KRGLIYGMGH AVYSISDPRA QIFKKFVKQL AEEKGRQKDY
QLYEMVERLA PQIIGQERHI YKGVSANVDF YSGFVYSMLE LPLELYTPMF AIARIVGWSA
HRMEELINTD KIIRPAYKNV LETQQYTTLT ER
//
